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231225s2021 xx |||||o 00| ||eng c |
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|a 10.1021/acs.langmuir.0c03396
|2 doi
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|a pubmed25n1066.xml
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|a eng
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|a Park, Hyeonjin
|e verfasserin
|4 aut
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|a Comparing Protein Adsorption onto Alumina and Silica Nanomaterial Surfaces
|b Clues for Vaccine Adjuvant Development
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|c 2021
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|a Date Completed 21.06.2021
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|a Date Revised 21.06.2021
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Protein adsorption onto nanomaterial surfaces is important for various nanobiotechnology applications such as biosensors and drug delivery. Within this scope, there is growing interest to develop alumina- and silica-based nanomaterial vaccine adjuvants and an outstanding need to compare protein adsorption onto alumina- and silica-based nanomaterial surfaces. Herein, using alumina- and silica-coated arrays of silver nanodisks with plasmonic properties, we conducted localized surface plasmon resonance (LSPR) experiments to evaluate real-time adsorption of bovine serum albumin (BSA) protein onto alumina and silica surfaces. BSA monomers and oligomers were prepared in different water-ethanol mixtures and both adsorbing species consistently showed quicker adsorption kinetics and more extensive adsorption-related spreading on alumina surfaces as compared to on silica surfaces. We rationalized these experimental observations in terms of the electrostatic forces governing protein-surface interactions on the two nanomaterial surfaces and the results support that more rigidly attached BSA protein-based coatings can be formed on alumina-based nanomaterial surfaces. Collectively, the findings in this study provide fundamental insight into protein-surface interactions at nanomaterial interfaces and can help to guide the development of protein-based coatings for medical and biotechnology applications such as vaccines
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Serum Albumin, Bovine
|2 NLM
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|a 27432CM55Q
|2 NLM
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|a Silicon Dioxide
|2 NLM
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|a 7631-86-9
|2 NLM
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|a Aluminum Oxide
|2 NLM
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|a LMI26O6933
|2 NLM
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| 700 |
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|a Ma, Gamaliel Junren
|e verfasserin
|4 aut
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|a Yoon, Bo Kyeong
|e verfasserin
|4 aut
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|a Cho, Nam-Joon
|e verfasserin
|4 aut
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|a Jackman, Joshua A
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1985
|g 37(2021), 3 vom: 26. Jan., Seite 1306-1314
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnas
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|g volume:37
|g year:2021
|g number:3
|g day:26
|g month:01
|g pages:1306-1314
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|u http://dx.doi.org/10.1021/acs.langmuir.0c03396
|3 Volltext
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