Investigating the Synergistic Interactions of Surface Immobilized and Free Natural Ocular Lubricants for Contact Lens Applications : A Comparative Study between Hyaluronic Acid and Proteoglycan 4 (Lubricin)

The main reasons for the discontinuation of contact lens wear are ocular dryness and discomfort. Proteoglycan 4 (PRG4), a mucinous glycoprotein, and hyaluronic acid (HA), a nonsulfated linear glycosaminoglycan, are naturally present in the eye and contribute to ocular hydration and lubrication. This...

Ausführliche Beschreibung

Bibliographische Detailangaben
Veröffentlicht in:Langmuir : the ACS journal of surfaces and colloids. - 1992. - 37(2021), 3 vom: 26. Jan., Seite 1062-1072
1. Verfasser: Korogiannaki, Myrto (VerfasserIn)
Weitere Verfasser: Samsom, Michael, Matheson, Austyn, Soliman, Karim, Schmidt, Tannin A, Sheardown, Heather
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2021
Zugriff auf das übergeordnete Werk:Langmuir : the ACS journal of surfaces and colloids
Schlagworte:Journal Article Research Support, Non-U.S. Gov't
LEADER 01000naa a22002652 4500
001 NLM319974014
003 DE-627
005 20231225172606.0
007 cr uuu---uuuuu
008 231225s2021 xx |||||o 00| ||eng c
024 7 |a 10.1021/acs.langmuir.0c02796  |2 doi 
028 5 2 |a pubmed24n1066.xml 
035 |a (DE-627)NLM319974014 
035 |a (NLM)33434030 
040 |a DE-627  |b ger  |c DE-627  |e rakwb 
041 |a eng 
100 1 |a Korogiannaki, Myrto  |e verfasserin  |4 aut 
245 1 0 |a Investigating the Synergistic Interactions of Surface Immobilized and Free Natural Ocular Lubricants for Contact Lens Applications  |b A Comparative Study between Hyaluronic Acid and Proteoglycan 4 (Lubricin) 
264 1 |c 2021 
336 |a Text  |b txt  |2 rdacontent 
337 |a ƒaComputermedien  |b c  |2 rdamedia 
338 |a ƒa Online-Ressource  |b cr  |2 rdacarrier 
500 |a Date Completed 02.02.2021 
500 |a Date Revised 02.02.2021 
500 |a published: Print-Electronic 
500 |a Citation Status PubMed-not-MEDLINE 
520 |a The main reasons for the discontinuation of contact lens wear are ocular dryness and discomfort. Proteoglycan 4 (PRG4), a mucinous glycoprotein, and hyaluronic acid (HA), a nonsulfated linear glycosaminoglycan, are naturally present in the eye and contribute to ocular hydration and lubrication. This study aimed to investigate the impact of the structure of the recombinant human PRG4 (rhPRG4)/HA complex on contact lens properties, when one agent is grafted and the counterpart is physisorbed on the surface of model conventional or silicone contact lens materials. Investigation of the wettability, water retention, antifouling, and boundary lubricant properties of the prepared hydrogels showed that the rhPRG4/HA interactions varied with the rhPRG/HA configuration on the hydrogel surface as well as the composition of the underlying substrate used. The rhPRG4-physisorbed/HA-grafted sample was characterized by better antifouling and boundary lubricant properties on the model conventional hydrogels, while the HA-physisorbed/rhPRG4-grafted sample exhibited improved surface wettability, antifouling, and water-retentive properties on the model silicone hydrogels. The results of this study contribute to the design of biomimetic contact lens surfaces that work synergistically with ocular fluid-phase biological agents to enhance compatibility between the contact lens and the ocular environment, alleviating dry eye symptoms and improving comfort 
650 4 |a Journal Article 
650 4 |a Research Support, Non-U.S. Gov't 
700 1 |a Samsom, Michael  |e verfasserin  |4 aut 
700 1 |a Matheson, Austyn  |e verfasserin  |4 aut 
700 1 |a Soliman, Karim  |e verfasserin  |4 aut 
700 1 |a Schmidt, Tannin A  |e verfasserin  |4 aut 
700 1 |a Sheardown, Heather  |e verfasserin  |4 aut 
773 0 8 |i Enthalten in  |t Langmuir : the ACS journal of surfaces and colloids  |d 1992  |g 37(2021), 3 vom: 26. Jan., Seite 1062-1072  |w (DE-627)NLM098181009  |x 1520-5827  |7 nnns 
773 1 8 |g volume:37  |g year:2021  |g number:3  |g day:26  |g month:01  |g pages:1062-1072 
856 4 0 |u http://dx.doi.org/10.1021/acs.langmuir.0c02796  |3 Volltext 
912 |a GBV_USEFLAG_A 
912 |a SYSFLAG_A 
912 |a GBV_NLM 
912 |a GBV_ILN_22 
912 |a GBV_ILN_350 
912 |a GBV_ILN_721 
951 |a AR 
952 |d 37  |j 2021  |e 3  |b 26  |c 01  |h 1062-1072