SARS-CoV-2 infection associated with hepatitis in an infant with X-linked severe combined immunodeficiency

Bibliographische Detailangaben
Veröffentlicht in:	Clinical immunology (Orlando, Fla.). - 1999. - 224(2021) vom: 04. März, Seite 108662
1. Verfasser:	van Oers, Nicolai S C (VerfasserIn)
Weitere Verfasser:	Hanners, Natasha W, Sue, Paul K, Aquino, Victor, Li, Quan-Zhen, Schoggins, John W, Wysocki, Christian A
Format:	Online-Aufsatz
Sprache:	English
Veröffentlicht:	2021
Zugriff auf das übergeordnete Werk:	Clinical immunology (Orlando, Fla.)
Schlagworte:	Case Reports Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Adaptive immunity COVID-19 Inborn errors of immunity SARS-CoV-2 Severe combined immunodeficiency

Beschreibung
Zusammenfassung:	Copyright © 2020 Elsevier Inc. All rights reserved. X-linked severe combined immunodeficiency (X-SCID) is a disorder of adaptive immunity caused by mutations in the IL-2 receptor common gamma chain gene resulting in deficiencies of T and natural killer cells, coupled with severe dysfunction in B cells. X-SCID is lethal without allogeneic stem cell transplant or gene therapy due to opportunistic infections. An infant with X-SCID became infected with SARS-CoV-2 while awaiting transplant. The patient developed severe hepatitis without the respiratory symptoms typical of COVID-19. He was treated with convalescent plasma, and thereafter was confirmed to have SARS-CoV-2 specific antibodies, as detected with a microfluidic antigen array. After resolution of the hepatitis, he received a haploidentical CD34 selected stem cell transplant, without conditioning, from his father who had recovered from COVID-19. SARS CoV-2 was detected via RT-PCR on nasopharyngeal swabs until 61 days post transplantation. He successfully engrafted donor T and NK cells, and continues to do well clinically
Beschreibung:	Date Completed 18.02.2021 Date Revised 21.12.2022 published: Print-Electronic Citation Status MEDLINE
ISSN:	1521-7035
DOI:	10.1016/j.clim.2020.108662