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231225s2021 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202007247
|2 doi
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|a pubmed25n1062.xml
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|a DE-627
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|a eng
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| 100 |
1 |
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|a Zeng, Ziling
|e verfasserin
|4 aut
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| 245 |
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|a Activatable Polymer Nanoenzymes for Photodynamic Immunometabolic Cancer Therapy
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|c 2021
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 24.07.2024
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|a Date Revised 24.07.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2020 Wiley-VCH GmbH.
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|a Tumor immunometabolism contributes substantially to tumor proliferation and immune cell activity, and thus plays a crucial role in the efficacy of cancer immunotherapy. Modulation of immunometabolism to boost cancer immunotherapy is mostly based on small-molecule inhibitors, which often encounter the issues of off-target adverse effects, drug resistance, and unsustainable response. In contrast, enzymatic therapeutics can potentially bypass these limitations but has been less exploited. Herein, an organic polymer nanoenzyme (SPNK) with near-infrared (NIR) photoactivatable immunotherapeutic effects is reported for photodynamic immunometabolic therapy. SPNK is composed of a semiconducting polymer core conjugated with kynureninase (KYNase) via PEGylated singlet oxygen (1 O2 ) cleavable linker. Upon NIR photoirradiation, SPNK generates 1 O2 not only to exert photodynamic effect to induce the immunogenic cell death of cancer, but also to unleash KYNase and trigger its activity to degrade the immunosuppressive kynurenine (Kyn). Such a combinational effect mediated by SPNK promotes the proliferation and infiltration of effector T cells, enhances systemic antitumor T cell immunity, and ultimately permits inhibition of both primary and distant tumors in living mice. Therefore, this study provides a promising photodynamic approach toward remotely controlled enzymatic immunomodulation for improved anticancer therapy
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|a Journal Article
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|a cancer therapy
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| 650 |
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4 |
|a immunotherapy
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| 650 |
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4 |
|a organic nanoparticles
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| 650 |
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4 |
|a photoactivation
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| 650 |
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4 |
|a photodynamic therapy
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| 650 |
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|a Polymers
|2 NLM
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| 650 |
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|a Singlet Oxygen
|2 NLM
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| 650 |
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|a 17778-80-2
|2 NLM
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| 650 |
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|a Photosensitizing Agents
|2 NLM
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| 700 |
1 |
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|a Zhang, Chi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Li, Jingchao
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Cui, Dong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Jiang, Yuyan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Pu, Kanyi
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 33(2021), 4 vom: 01. Jan., Seite e2007247
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnas
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| 773 |
1 |
8 |
|g volume:33
|g year:2021
|g number:4
|g day:01
|g month:01
|g pages:e2007247
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| 856 |
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|u http://dx.doi.org/10.1002/adma.202007247
|3 Volltext
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