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231225s2021 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202004225
|2 doi
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|a pubmed25n1061.xml
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|a (NLM)33270303
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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|a Guo, Zhengqing
|e verfasserin
|4 aut
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| 245 |
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|a Heavy-Atom-Modulated Supramolecular Assembly Increases Antitumor Potency against Malignant Breast Tumors via Tunable Cooperativity
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|c 2021
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 24.07.2024
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|a Date Revised 24.07.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2020 Wiley-VCH GmbH.
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|a Triple-negative breast cancer (TNBC) remains with highest incidence and mortality rates among females, and a critical bottleneck lies in rationally establishing potent therapeutics against TNBC. Here, the self-assembled micellar nanoarchitecture of heavy-atom-modulated supramolecules with efficient cytoplasmic translocation and tunable photoconversion is shown, for potent suppression against primary, metastatic, and recurrent TNBC. Multi-iodinated boron dipyrromethene micelles yield tunable photoconversion into singlet oxygen and a thermal effect, together with deep penetration and subsequent cytoplasmic translocation at the tumor. Tetra-iodinated boron dipyrromethene micelles (4-IBMs) particularly show a distinctly enhanced cooperativity of antitumor efficiency through considerable expressions of apoptotic proteins, potently suppressing subcutaneous, and orthotopic TNBC models, together with reduced oxygen dependence. Furthermore, 4-IBMs yield preferable anti-metastatic and anti-recurrent efficacies through the inhibition of metastasis-relevant proteins, distinct immunogenic cell death, and re-education of M2 macrophages into tumoricidal M1 phenotype as compared to chemotherapy and surgical resection. These results offer insights into the cooperativity of supramolecular nanoarchitectures for potent phototherapy against TNBC
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|a Journal Article
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|a micelles
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|a nanomedicine
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|a phototherapy
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|a self-assembly
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|a tumor metastasis
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|a Micelles
|2 NLM
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| 650 |
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|a Antineoplastic Agents
|2 NLM
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| 650 |
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|a dipyrromethene
|2 NLM
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| 650 |
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|a Boron Compounds
|2 NLM
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| 650 |
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|a Porphobilinogen
|2 NLM
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| 650 |
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|a 74KHC72QXK
|2 NLM
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| 700 |
1 |
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|a He, Hui
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Yi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Rao, Jiaming
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yang, Tao
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Li, Ting
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Lu
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Shi, Mengke
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Mengya
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Qiu, Shihong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Song, Xue
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ke, Hengte
|e verfasserin
|4 aut
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| 700 |
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|a Chen, Huabing
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 33(2021), 2 vom: 15. Jan., Seite e2004225
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnas
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| 773 |
1 |
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|g volume:33
|g year:2021
|g number:2
|g day:15
|g month:01
|g pages:e2004225
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| 856 |
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|u http://dx.doi.org/10.1002/adma.202004225
|3 Volltext
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