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231225s2021 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202004917
|2 doi
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|a pubmed24n1481.xml
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|a eng
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|a Wang, Jin
|e verfasserin
|4 aut
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|a An Ultrahigh-Field-Tailored T1 -T2 Dual-Mode MRI Contrast Agent for High-Performance Vascular Imaging
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|c 2021
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 24.07.2024
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|a Date Revised 24.07.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2020 Wiley-VCH GmbH.
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|a The assessment of vascular anatomy and functions using magnetic resonance imaging (MRI) is critical for medical diagnosis, whereas the commonly used low-field MRI system (≤3 T) suffers from low spatial resolution. Ultrahigh field (UHF) MRI (≥7 T), with significantly improved resolution and signal-to-noise ratio, shows great potential to provide high-resolution vasculature images. However, practical applications of UHF MRI technology for vascular imaging are currently limited by the low sensitivity and accuracy of single-mode (T1 or T2 ) contrast agents. Herein, a UHF-tailored T1 -T2 dual-mode iron oxide nanoparticle-based contrast agent (UDIOC) with extremely small core size and ultracompact hydrophilic surface modification, exhibiting dually enhanced T1 -T2 contrast effect under the 7 T magnetic field, is reported. The UDIOC enables clear visualization of microvasculature as small as ≈140 µm in diameter under UHF MRI, extending the detection limit of the 7 T MR angiography. Moreover, by virtue of high-resolution UHF MRI and a simple double-checking process, UDIOC-based dual-mode dynamic contrast-enhanced MRI is successfully applied to detect tumor vascular permeability with extremely high sensitivity and accuracy, providing a novel paradigm for the precise medical diagnosis of vascular-related diseases
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|a Journal Article
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|a DCE-MRI
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|a MRI contrast agents
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|a dual-mode contrast agents
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|a magnetic nanoparticles
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|a vascular imaging
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|a Contrast Media
|2 NLM
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| 700 |
1 |
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|a Jia, Yinhang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Qiyue
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Liang, Zeyu
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Han, Guangxu
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Zejun
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lee, Jiyoung
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhao, Meng
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Li, Fangyuan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Bai, Ruiliang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ling, Daishun
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 33(2021), 2 vom: 01. Jan., Seite e2004917
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|g volume:33
|g year:2021
|g number:2
|g day:01
|g month:01
|g pages:e2004917
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|u http://dx.doi.org/10.1002/adma.202004917
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