|
|
|
|
| LEADER |
01000caa a22002652 4500 |
| 001 |
NLM318202239 |
| 003 |
DE-627 |
| 005 |
20240804231950.0 |
| 007 |
cr uuu---uuuuu |
| 008 |
231225s2021 xx |||||o 00| ||eng c |
| 024 |
7 |
|
|a 10.1016/j.clim.2020.108642
|2 doi
|
| 028 |
5 |
2 |
|a pubmed24n1491.xml
|
| 035 |
|
|
|a (DE-627)NLM318202239
|
| 035 |
|
|
|a (NLM)33253854
|
| 035 |
|
|
|a (PII)S1521-6616(20)30802-0
|
| 040 |
|
|
|a DE-627
|b ger
|c DE-627
|e rakwb
|
| 041 |
|
|
|a eng
|
| 100 |
1 |
|
|a Jin, Xiao-Hong
|e verfasserin
|4 aut
|
| 245 |
1 |
0 |
|a Peripheral immunological features of COVID-19 patients in Taizhou, China
|b A retrospective study
|
| 264 |
|
1 |
|c 2021
|
| 336 |
|
|
|a Text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a ƒaComputermedien
|b c
|2 rdamedia
|
| 338 |
|
|
|a ƒa Online-Ressource
|b cr
|2 rdacarrier
|
| 500 |
|
|
|a Date Completed 28.01.2021
|
| 500 |
|
|
|a Date Revised 04.08.2024
|
| 500 |
|
|
|a published: Print-Electronic
|
| 500 |
|
|
|a Citation Status MEDLINE
|
| 520 |
|
|
|a Copyright © 2020 Elsevier Inc. All rights reserved.
|
| 520 |
|
|
|a BACKGROUND: Abnormal peripheral immunological features are associated with the progression of coronavirus disease 2019 (COVID-19)
|
| 520 |
|
|
|a METHODS: Clinical and laboratory data were retrieved in a cohort of 146 laboratory-confirmed COVID-19 patients. Potential risk factors for the development of severe COVID-19 were evaluated
|
| 520 |
|
|
|a RESULTS: On admission, lymphocytes, CD3+, CD4+ and CD8+ T cells, eosinophils, and albumin and pre-albumin were dramatically lower, whereas neutrophils, and interleukin (IL)-10, C-reactive protein (CRP), aspartate aminotransferase (AST) and gamma-glutamyltransferase (GGT) were significantly higher in severe cases. By the second week after discharge, all variables improved to normal levels. Covariate logistic regression results showed that the CD8+ cell count and CRP level were independent risk factors for severe COVID-19
|
| 520 |
|
|
|a CONCLUSION: Lower peripheral immune cell subsets in patients with severe disease recovered to normal levels as early as the second week after discharge. CD8+ T cell counts and CRP levels on admission are independent predictive factors for severe COVID-19
|
| 650 |
|
4 |
|a Journal Article
|
| 650 |
|
4 |
|a Research Support, Non-U.S. Gov't
|
| 650 |
|
4 |
|a COVID-19
|
| 650 |
|
4 |
|a Follow-up
|
| 650 |
|
4 |
|a Immune cells
|
| 650 |
|
4 |
|a Predictive factor
|
| 650 |
|
4 |
|a Severity
|
| 650 |
|
7 |
|a Cytokines
|2 NLM
|
| 650 |
|
7 |
|a Serum Albumin
|2 NLM
|
| 700 |
1 |
|
|a Zhou, Hui-Li
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Chen, Ling-Ling
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Wang, Guan-Fu
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Han, Qiu-Yue
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Zhang, Jian-Gang
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Zhang, Xia
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Chen, Qiong-Yuan
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Ye, Yao-Han
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Lin, Aifen
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Yan, Wei-Hua
|e verfasserin
|4 aut
|
| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 222(2021) vom: 25. Jan., Seite 108642
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
|
| 773 |
1 |
8 |
|g volume:222
|g year:2021
|g day:25
|g month:01
|g pages:108642
|
| 856 |
4 |
0 |
|u http://dx.doi.org/10.1016/j.clim.2020.108642
|3 Volltext
|
| 912 |
|
|
|a GBV_USEFLAG_A
|
| 912 |
|
|
|a SYSFLAG_A
|
| 912 |
|
|
|a GBV_NLM
|
| 912 |
|
|
|a GBV_ILN_11
|
| 912 |
|
|
|a GBV_ILN_24
|
| 912 |
|
|
|a GBV_ILN_350
|
| 951 |
|
|
|a AR
|
| 952 |
|
|
|d 222
|j 2021
|b 25
|c 01
|h 108642
|