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231225s2020 xx |||||o 00| ||eng c |
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|a 10.1021/acs.langmuir.0c02224
|2 doi
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|a pubmed24n1059.xml
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|a (DE-627)NLM317780808
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|a (NLM)33210931
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
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|a Oseliero Filho, Pedro Leonidas
|e verfasserin
|4 aut
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| 245 |
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|a Structure and Thermotropic Behavior of Bovine- and Porcine-Derived Exogenous Lung Surfactants
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|c 2020
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 21.06.2021
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|a Date Revised 21.06.2021
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Two commercial exogenous pulmonary surfactants, Curosurf and Survanta, are investigated. Their thermotropic behavior and associated structural changes for the samples in bulk are characterized and described. For Survanta, the obtained results of differential scanning calorimetry showed a thermogram with three peaks on heating and only a single peak on cooling. Curosurf on the other hand, presents calorimetric thermograms with only one peak in both the heating and cooling scans. This distinct thermotropic behavior between the two pulmonary surfactants, a consequence of their particular compositions, is associated with structural changes that were evaluated by simultaneous small- and wide-angle X-ray scattering experiments with in situ temperature variation. Interestingly, for temperatures below ∼35 °C for Curosurf and ∼53 °C for Survanta, the scattering data indicated the coexistence of two lamellar phases with different carbon chain organizations. For temperatures above these limits, the coexistence of phases disappears, giving rise to a fluid phase in both pulmonary surfactants, with multilamelar vesicles for Curosurf and unilamellar vesicles for Survanta. This process is quasi-reversible under cooling, and advanced data analysis for the scattering data indicated differences in the structural and elastic properties of the pulmonary surfactants. The detailed and systematic investigation shown in this work expands on the knowledge of the structure and thermodynamic behavior of Curosurf and Survanta, being relevant from both physiological and biophysical perspectives and also providing a basis for further studies on other types of pulmonary surfactants
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Pulmonary Surfactants
|2 NLM
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|a Surface-Active Agents
|2 NLM
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| 700 |
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|a Gerbelli, Barbara Bianca
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Fornasier, Franccesca
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chaves Filho, Adriano B
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yoshinaga, Marcos Yukio
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Miyamoto, Sayuri
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Mortara, Laura
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lacerda, Caroline Dutra
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Cuccovia, Iolanda Midea
|e verfasserin
|4 aut
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| 700 |
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|a Pimentel, André Silva
|e verfasserin
|4 aut
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| 700 |
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|a Oliveira, Cristiano Luis Pinto
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 36(2020), 48 vom: 08. Dez., Seite 14514-14529
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
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|g volume:36
|g year:2020
|g number:48
|g day:08
|g month:12
|g pages:14514-14529
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