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231225s2020 xx |||||o 00| ||eng c |
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|a 10.1155/2020/8815990
|2 doi
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|a eng
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| 100 |
1 |
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|a Wei, Mei
|e verfasserin
|4 aut
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| 245 |
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|a Protection of Cochlear Ribbon Synapses and Prevention of Hidden Hearing Loss
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|c 2020
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|a Text
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|a ƒaComputermedien
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 29.09.2021
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|a Date Revised 29.09.2021
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|a published: Electronic-eCollection
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|a Citation Status MEDLINE
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|a Copyright © 2020 Mei Wei et al.
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|a In the auditory system, ribbon synapses are vesicle-associated structures located between inner hair cells (IHCs) and spiral ganglion neurons that are implicated in the modulation of trafficking and fusion of synaptic vesicles at the presynaptic terminals. Synapse loss may result in hearing loss and difficulties with understanding speech in a noisy environment. This phenomenon happens without permanent hearing loss; that is, the cochlear synaptopathy is "hidden." Recent studies have reported that synapse loss might be critical in the pathogenesis of hidden hearing loss. A better understanding of the molecular mechanisms of the formation, structure, regeneration, and protection of ribbon synapses will assist in the design of potential therapeutic strategies. In this review, we describe and summarize the following aspects of ribbon synapses: (1) functional and structural features, (2) potential mechanisms of damage, (3) therapeutic research on protecting the synapses, and (4) the role of synaptic regeneration in auditory neuropathy and the current options for synapse rehabilitation
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Review
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|a Wang, Wei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Liu, Yao
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Mao, Xiang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chen, Tai Sheng
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lin, Peng
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Neural plasticity
|d 1998
|g 2020(2020) vom: 31., Seite 8815990
|w (DE-627)NLM098558390
|x 1687-5443
|7 nnas
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| 773 |
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|g volume:2020
|g year:2020
|g day:31
|g pages:8815990
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|u http://dx.doi.org/10.1155/2020/8815990
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|d 2020
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|h 8815990
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