Multiple Molecular Dynamics Simulations of the Inhibitor GRL-02031 Complex with Wild Type and Mutant HIV-1 Protease Reveal the Binding and Drug-Resistance Mechanism
Human immunodeficiency virus type 1 (HIV-1) protease is regarded as a fascinating target for drug development against HIV infection. However, mutations causing drug resistance severely limit the efficiency of the recently marketed drugs in the treatment of HIV replication. To elucidate the binding m...
| Publié dans: | Langmuir : the ACS journal of surfaces and colloids. - 1985. - 36(2020), 46 vom: 24. Nov., Seite 13817-13832 |
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| Format: | Article en ligne |
| Langue: | English |
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2020
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| Accès à la collection: | Langmuir : the ACS journal of surfaces and colloids |
| Sujets: | Journal Article Carbamates GRL 02031 HIV Protease Inhibitors Pharmaceutical Preparations Sulfonamides Peptide Hydrolases EC 3.4.- HIV Protease EC 3.4.23.- |
| Accès en ligne |
Volltext |