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231225s2020 xx |||||o 00| ||eng c |
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|a 10.1021/acs.langmuir.0c01813
|2 doi
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|a pubmed24n1054.xml
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|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Andreev, Konstantin
|e verfasserin
|4 aut
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| 245 |
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|a Structural Changes in Films of Pulmonary Surfactant Induced by Surfactant Vesicles
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|c 2020
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|a Date Completed 21.06.2021
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|a Date Revised 14.01.2022
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a When compressed by the shrinking alveolar surface area during exhalation, films of pulmonary surfactant in situ reduce surface tension to levels at which surfactant monolayers collapse from the surface in vitro. Vesicles of pulmonary surfactant added below these monolayers slow collapse. X-ray scattering here determined the structural changes induced by the added vesicles. Grazing incidence X-ray diffraction on monolayers of extracted calf surfactant detected an ordered phase. Mixtures of dipalmitoyl phosphatidylcholine and cholesterol, but not the phospholipid alone, mimic that structure. At concentrations that stabilize the monolayers, vesicles in the subphase had no effect on the unit cell, and X-ray reflection showed that the film remained monomolecular. The added vesicles, however, produced a concentration-dependent increase in the diffracted intensity. These results suggest that the enhanced resistance to collapse results from enlargement by the additional material of the ordered phase
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|a Journal Article
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|a Research Support, N.I.H., Extramural
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|a Research Support, U.S. Gov't, Non-P.H.S.
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|a Phospholipids
|2 NLM
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|a Pulmonary Surfactants
|2 NLM
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|a Surface-Active Agents
|2 NLM
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|a 1,2-Dipalmitoylphosphatidylcholine
|2 NLM
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|a 2644-64-6
|2 NLM
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|a Martynowycz, Michael W
|e verfasserin
|4 aut
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1 |
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|a Kuzmenko, Ivan
|e verfasserin
|4 aut
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1 |
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|a Bu, Wei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Hall, Stephen B
|e verfasserin
|4 aut
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| 700 |
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|a Gidalevitz, David
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1999
|g 36(2020), 45 vom: 17. Nov., Seite 13439-13447
|w (DE-627)NLM098181009
|x 1520-5827
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| 773 |
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|g volume:36
|g year:2020
|g number:45
|g day:17
|g month:11
|g pages:13439-13447
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|u http://dx.doi.org/10.1021/acs.langmuir.0c01813
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