Prediction of Chronic Inflammation for Inhaled Particles the Impact of Material Cycling and Quarantining in the Lung Epithelium

Prediction of Chronic Inflammation for Inhaled Particles : the Impact of Material Cycling and Quarantining in the Lung Epithelium

© 2020 The Authors. Published by Wiley-VCH GmbH.

Détails bibliographiques
Publié dans:Advanced materials (Deerfield Beach, Fla.). - 1998. - 32(2020), 47 vom: 19. Nov., Seite e2003913
Auteur principal: Kokot, Hana (Auteur)
Autres auteurs: Kokot, Boštjan, Sebastijanović, Aleksandar, Voss, Carola, Podlipec, Rok, Zawilska, Patrycja, Berthing, Trine, Ballester-López, Carolina, Danielsen, Pernille Høgh, Contini, Claudia, Ivanov, Mikhail, Krišelj, Ana, Čotar, Petra, Zhou, Qiaoxia, Ponti, Jessica, Zhernovkov, Vadim, Schneemilch, Matthew, Doumandji, Zahra, Pušnik, Mojca, Umek, Polona, Pajk, Stane, Joubert, Olivier, Schmid, Otmar, Urbančič, Iztok, Irmler, Martin, Beckers, Johannes, Lobaskin, Vladimir, Halappanavar, Sabina, Quirke, Nick, Lyubartsev, Alexander P, Vogel, Ulla, Koklič, Tilen, Stoeger, Tobias, Štrancar, Janez
Format: Article en ligne
Langue:English
Publié: 2020
Accès à la collection:Advanced materials (Deerfield Beach, Fla.)
Sujets:Journal Article advanced microscopies adverse outcome pathways disease prediction material safety and health hazards mode of action Particulate Matter
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520 |a On a daily basis, people are exposed to a multitude of health-hazardous airborne particulate matter with notable deposition in the fragile alveolar region of the lungs. Hence, there is a great need for identification and prediction of material-associated diseases, currently hindered due to the lack of in-depth understanding of causal relationships, in particular between acute exposures and chronic symptoms. By applying advanced microscopies and omics to in vitro and in vivo systems, together with in silico molecular modeling, it is determined herein that the long-lasting response to a single exposure can originate from the interplay between the newly discovered nanomaterial quarantining and nanomaterial cycling between different lung cell types. This new insight finally allows prediction of the spectrum of lung inflammation associated with materials of interest using only in vitro measurements and in silico modeling, potentially relating outcomes to material properties for a large number of materials, and thus boosting safe-by-design-based material development. Because of its profound implications for animal-free predictive toxicology, this work paves the way to a more efficient and hazard-free introduction of numerous new advanced materials into our lives 
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700 1 |a Kokot, Boštjan  |e verfasserin  |4 aut 
700 1 |a Sebastijanović, Aleksandar  |e verfasserin  |4 aut 
700 1 |a Voss, Carola  |e verfasserin  |4 aut 
700 1 |a Podlipec, Rok  |e verfasserin  |4 aut 
700 1 |a Zawilska, Patrycja  |e verfasserin  |4 aut 
700 1 |a Berthing, Trine  |e verfasserin  |4 aut 
700 1 |a Ballester-López, Carolina  |e verfasserin  |4 aut 
700 1 |a Danielsen, Pernille Høgh  |e verfasserin  |4 aut 
700 1 |a Contini, Claudia  |e verfasserin  |4 aut 
700 1 |a Ivanov, Mikhail  |e verfasserin  |4 aut 
700 1 |a Krišelj, Ana  |e verfasserin  |4 aut 
700 1 |a Čotar, Petra  |e verfasserin  |4 aut 
700 1 |a Zhou, Qiaoxia  |e verfasserin  |4 aut 
700 1 |a Ponti, Jessica  |e verfasserin  |4 aut 
700 1 |a Zhernovkov, Vadim  |e verfasserin  |4 aut 
700 1 |a Schneemilch, Matthew  |e verfasserin  |4 aut 
700 1 |a Doumandji, Zahra  |e verfasserin  |4 aut 
700 1 |a Pušnik, Mojca  |e verfasserin  |4 aut 
700 1 |a Umek, Polona  |e verfasserin  |4 aut 
700 1 |a Pajk, Stane  |e verfasserin  |4 aut 
700 1 |a Joubert, Olivier  |e verfasserin  |4 aut 
700 1 |a Schmid, Otmar  |e verfasserin  |4 aut 
700 1 |a Urbančič, Iztok  |e verfasserin  |4 aut 
700 1 |a Irmler, Martin  |e verfasserin  |4 aut 
700 1 |a Beckers, Johannes  |e verfasserin  |4 aut 
700 1 |a Lobaskin, Vladimir  |e verfasserin  |4 aut 
700 1 |a Halappanavar, Sabina  |e verfasserin  |4 aut 
700 1 |a Quirke, Nick  |e verfasserin  |4 aut 
700 1 |a Lyubartsev, Alexander P  |e verfasserin  |4 aut 
700 1 |a Vogel, Ulla  |e verfasserin  |4 aut 
700 1 |a Koklič, Tilen  |e verfasserin  |4 aut 
700 1 |a Stoeger, Tobias  |e verfasserin  |4 aut 
700 1 |a Štrancar, Janez  |e verfasserin  |4 aut 
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