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231225s2020 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202002873
|2 doi
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|a pubmed24n1054.xml
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|a (DE-627)NLM31627786X
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|a (NLM)33058247
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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|a Gleeson, Matthew
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Quantitative Polarization-Resolved Second-Harmonic-Generation Microscopy of Glycine Microneedles
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|c 2020
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 20.08.2021
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|a Date Revised 20.08.2021
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2020 Wiley-VCH GmbH.
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|a Second-harmonic generation (SHG) is a nonlinear optical process that can provide disease diagnosis through characterization of biological building blocks such as amino acids, peptides, and proteins. The second-order nonlinear susceptibility tensor χ(2) of a material characterizes its tendency to cause SHG. Here, a method for finding the χ(2) elements from polarization-resolved SHG microscopy in transmission mode is presented. The quantitative framework and analytical approach that corrects for micrometer-scale morphology and birefringence enable the determination and comparison of the SHG susceptibility tensors of β- and γ-phase glycine microneedles. The maximum nonlinear susceptibility coefficients are d33 = 15 pm V-1 for the β and d33 = 5.9 pm V-1 for the γ phase. The results demonstrate glycine as a useful biocompatible nonlinear material. This combination of the analytical model and polarization-resolved SHG transmission microscopy is broadly applicable for quantitative SHG material characterization and diagnostic imaging
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|a Journal Article
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|a biomolecules
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| 650 |
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4 |
|a biophotonics
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| 650 |
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4 |
|a molecular crystal allomorphs
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| 650 |
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|a Glycine
|2 NLM
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| 650 |
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|a TE7660XO1C
|2 NLM
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| 700 |
1 |
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|a O'Dwyer, Kevin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Guerin, Sarah
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Rice, Daragh
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Thompson, Damien
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Tofail, Syed A M
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Silien, Christophe
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Liu, Ning
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 32(2020), 46 vom: 16. Nov., Seite e2002873
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
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| 773 |
1 |
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|g volume:32
|g year:2020
|g number:46
|g day:16
|g month:11
|g pages:e2002873
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| 856 |
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|u http://dx.doi.org/10.1002/adma.202002873
|3 Volltext
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