Emerging Prospects of Exosomes for Cancer Treatment : From Conventional Therapy to Immunotherapy

© 2020 The Authors. Published by Wiley-VCH GmbH.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 32(2020), 51 vom: 01. Dez., Seite e2002440
1. Verfasser: Nam, Gi-Hoon (VerfasserIn)
Weitere Verfasser: Choi, Yoonjeong, Kim, Gi Beom, Kim, Seohyun, Kim, Seong A, Kim, In-San
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2020
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article Review cancer therapeutics characterization and clinical-grade exosomes exosomes extracellular vesicles immunotherapy
Beschreibung
Zusammenfassung:© 2020 The Authors. Published by Wiley-VCH GmbH.
Exosomes are a class of extracellular vesicles of around 100 nm in diameter that are secreted by most cells and contain various bioactive molecules reflecting their cellular origin and mediate intercellular communication. Studies of these exosomal features in tumor pathogenesis have led to the development of therapeutic and diagnostic approaches using exosomes for cancer therapy. Exosomes have many advantages for conveying therapeutic agents such as small interfering RNAs, microRNAs, membrane-associated proteins, and chemotherapeutic compounds; thus, they are considered a prime candidate as a delivery tool for cancer treatment. Since exosomes also provide an optimal microenvironment for the effective function of immunomodulatory factors, exosomes harboring bioactive molecules have been bioengineered as cancer immunotherapies that can effectively activate each stage of the cancer immunity cycle to successfully elicit cancer-specific immunity. This review discusses the advantages of exosomes for treating cancer and the challenges that must be overcome for their successful clinical development
Beschreibung:Date Completed 24.07.2024
Date Revised 24.07.2024
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-4095
DOI:10.1002/adma.202002440