Near-Infrared AIE Dots with Chemiluminescence for Deep-Tissue Imaging
© 2020 Wiley-VCH GmbH.
| Publié dans: | Advanced materials (Deerfield Beach, Fla.). - 1998. - 32(2020), 43 vom: 10. Okt., Seite e2004685 |
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| Auteur principal: | |
| Autres auteurs: | , , , , , , |
| Format: | Article en ligne |
| Langue: | English |
| Publié: |
2020
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| Accès à la collection: | Advanced materials (Deerfield Beach, Fla.) |
| Sujets: | Journal Article aggregation-induced emission cancer diagnosis deep-tissue imaging near-infrared chemiluminescence |
| Résumé: | © 2020 Wiley-VCH GmbH. Near-infrared (NIR) chemiluminescence (CL) emission is highly favorable for deep-tissue imaging, but chemically conjugated NIR CL emitters with the aggregation-induced emission (AIE) property for biotechnology are seldom reported. Herein, an AIE-active NIR CL emitter, TBL, is synthesized by conjugating luminol unit with electron-accepting benzothiadiazole and an electron-donating triphenylamine, and subsequently TBL dots are prepared by using F127 as the surfactant. The CL emission of TBL dots can last continuously for over 60 min and can be employed for quantitative (in vitro) and qualitative (in vivo) detection of 1 O2 . Strikingly, the NIR CL emission can penetrate through tissues with a total thickness of over 3 cm, exhibiting significantly better performance than NIR fluorescence emission and blue CL emission. Moreover, the successful differentiation of tumor and normal tissues by TBL-based CL imaging in vivo also paves the way for CL-guided cancer diagnosis and surgery |
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| Description: | Date Completed 19.07.2021 Date Revised 19.07.2021 published: Print-Electronic Citation Status MEDLINE |
| ISSN: | 1521-4095 |
| DOI: | 10.1002/adma.202004685 |