GSH-Depleted Nanozymes with Hyperthermia-Enhanced Dual Enzyme-Mimic Activities for Tumor Nanocatalytic Therapy

© 2020 Wiley-VCH GmbH.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 32(2020), 42 vom: 01. Okt., Seite e2002439
1. Verfasser: Dong, Shuming (VerfasserIn)
Weitere Verfasser: Dong, Yushan, Jia, Tao, Liu, Shikai, Liu, Jing, Yang, Dan, He, Fei, Gai, Shili, Yang, Piaoping, Lin, Jun
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2020
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article catalase-mimics glutathione depletion nanozymes peroxidase-mimics tumor nanocatalytic therapy Cerium 30K4522N6T Polyethylene Glycols 3WJQ0SDW1A mehr... ceric oxide 619G5K328Y Silicon Dioxide 7631-86-9 Glutathione GAN16C9B8O
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520 |a Nanocatalytic therapy, using artificial nanoscale enzyme mimics (nanozymes), is an emerging technology for therapeutic treatment of various malignant tumors. However, the relatively deficient catalytic activity of nanozymes in the tumor microenvironment (TME) restrains their biomedical applications. Here, a versatile and bacteria-like PEG/Ce-BiDMSN nanozyme is developed by coating uniform Bi2 S3 nanorods (NRs) with dendritic mesoporous silica (Bi2 S3 @DMSN) and then decorating ultrasmall ceria nanozymes into the large mesopores of Bi2 S3 @DMSN. The nanozymes exhibit dual enzyme-mimic catalytic activities (peroxidase-mimic and catalase-mimic) under acidic conditions that can regulate the TME, that is, simultaneously elevate oxidative stress and relieve hypoxia. In addition, the nanozymes can effectively consume the overexpressed glutathione (GSH) through redox reaction. Photothermal therapy (PTT) is introduced to synergistically improve the dual enzyme-mimicking catalytic activities and depletion of the overexpressed GSH in the tumors by photonic hyperthermia. This is achieved by taking advantage of the desirable light absorbance in the second near-infrared (NIR-II) window of the PEG/Ce-Bi@DMSN nanozymes. Subsequently the reactive oxygen species (ROS)-mediated therapeutic efficiency is significantly improved. Therefore, this study provides a proof of concept of hyperthermia-augmented multi-enzymatic activities of nanozymes for tumor ablation 
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650 4 |a glutathione depletion 
650 4 |a nanozymes 
650 4 |a peroxidase-mimics 
650 4 |a tumor nanocatalytic therapy 
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650 7 |a Polyethylene Glycols  |2 NLM 
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650 7 |a ceric oxide  |2 NLM 
650 7 |a 619G5K328Y  |2 NLM 
650 7 |a Silicon Dioxide  |2 NLM 
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650 7 |a Glutathione  |2 NLM 
650 7 |a GAN16C9B8O  |2 NLM 
700 1 |a Dong, Yushan  |e verfasserin  |4 aut 
700 1 |a Jia, Tao  |e verfasserin  |4 aut 
700 1 |a Liu, Shikai  |e verfasserin  |4 aut 
700 1 |a Liu, Jing  |e verfasserin  |4 aut 
700 1 |a Yang, Dan  |e verfasserin  |4 aut 
700 1 |a He, Fei  |e verfasserin  |4 aut 
700 1 |a Gai, Shili  |e verfasserin  |4 aut 
700 1 |a Yang, Piaoping  |e verfasserin  |4 aut 
700 1 |a Lin, Jun  |e verfasserin  |4 aut 
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773 1 8 |g volume:32  |g year:2020  |g number:42  |g day:01  |g month:10  |g pages:e2002439 
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