Systematical NMR analysis of swainsonine, a mycotoxin from endophytic fungus Alternaria oxytropis
© 2020 John Wiley & Sons, Ltd.
| Veröffentlicht in: | Magnetic resonance in chemistry : MRC. - 1985. - 59(2021), 1 vom: 15. Jan., Seite 16-22 |
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| 1. Verfasser: | |
| Weitere Verfasser: | , , , , |
| Format: | Online-Aufsatz |
| Sprache: | English |
| Veröffentlicht: |
2021
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| Zugriff auf das übergeordnete Werk: | Magnetic resonance in chemistry : MRC |
| Schlagworte: | Journal Article Research Support, Non-U.S. Gov't Alternaria oxytropis NMR endophytic fungus structural elucidation swainsonine Mycotoxins Swainsonine RSY4RK37KQ |
| Zusammenfassung: | © 2020 John Wiley & Sons, Ltd. Swainsonine (SW, 1), a unique indolizine with poly-hydroxyl groups, was re-isolated from the plant endophytic fungus Alternaria oxytropis. The structure (including planar structure and relative configuration) was systematically elucidated by NMR spectra (including 1 H, 13 C, 1 H-1 H COSY, HMQC, HMBC, and NOESY spectra in DMSO-d6 and in CD3 OD); 1 H NMR spectra of the modified Mosher's products were first used to determine the absolute configuration of SW. More importantly, the complex coupled features of H-7α, H-7β, and H-6α in the 1 H NMR spectrum of (1) were analyzed in details, which will provide aids for the planar and relative configuration determination of analogs |
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| Beschreibung: | Date Completed 19.07.2021 Date Revised 19.07.2021 published: Print-Electronic Citation Status MEDLINE |
| ISSN: | 1097-458X |
| DOI: | 10.1002/mrc.5098 |