|
|
|
|
| LEADER |
01000caa a22002652c 4500 |
| 001 |
NLM314806849 |
| 003 |
DE-627 |
| 005 |
20250227232325.0 |
| 007 |
cr uuu---uuuuu |
| 008 |
231225s2021 xx |||||o 00| ||eng c |
| 024 |
7 |
|
|a 10.1016/j.cej.2020.126854
|2 doi
|
| 028 |
5 |
2 |
|a pubmed25n1049.xml
|
| 035 |
|
|
|a (DE-627)NLM314806849
|
| 035 |
|
|
|a (NLM)32908446
|
| 040 |
|
|
|a DE-627
|b ger
|c DE-627
|e rakwb
|
| 041 |
|
|
|a eng
|
| 100 |
1 |
|
|a Li, Xiang
|e verfasserin
|4 aut
|
| 245 |
1 |
2 |
|a A metagenomic-based method to study hospital air dust resistome
|
| 264 |
|
1 |
|c 2021
|
| 336 |
|
|
|a Text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a ƒaComputermedien
|b c
|2 rdamedia
|
| 338 |
|
|
|a ƒa Online-Ressource
|b cr
|2 rdacarrier
|
| 500 |
|
|
|a Date Revised 12.11.2023
|
| 500 |
|
|
|a published: Print-Electronic
|
| 500 |
|
|
|a Citation Status PubMed-not-MEDLINE
|
| 520 |
|
|
|a © 2020 Elsevier B.V. All rights reserved.
|
| 520 |
|
|
|a As a symbol of the defense mechanisms that bacteria have evolved over time, the genes that make bacteria resist antibiotics are overwhelmingly present in the environment. Currently, bacterial antibiotic resistance genes (ARGs) in the air are a serious concern. Previous studies have identified bacterial communities and summarized putative routes of transmissions for some dominant hospital-associated pathogens from hospital indoor samples. However, little is known about the possible indoor air ARG transportation. In this study, we mainly surveyed air-conditioner air dust samples under different airflow conditions and analyzed these samples using a metagenomic-based method. The results show air dust samples exhibited a complex resistome, and the average concentration is 0.00042 copies/16S rRNA gene, which is comparable to some other environments. The hospital air-conditioners can form resistome over time and accumulate pathogens. In addition, our results indicate that the Outpatient hall is one of the main ARG transmission sources, which can distribute ARGs to other departments (explains >80% resistome). We believe that the management should focus on ARG carrier genera such as Staphylococcus, Micrococcus, Streptococcus, and Enterococcus in this hospital and our novel evidence-based network strategy proves that plasmid-mediated ARG transfer can occur frequently. Overall, these results provide insights into the characteristics of air dust resistome and possible route for how ARGs are spread in air
|
| 650 |
|
4 |
|a Journal Article
|
| 650 |
|
4 |
|a Air dust
|
| 650 |
|
4 |
|a Antibiotic resistance genes
|
| 650 |
|
4 |
|a Metagenomic-based method
|
| 650 |
|
4 |
|a Plasmid-mediated ARG transfer
|
| 650 |
|
4 |
|a Resistome
|
| 700 |
1 |
|
|a Wu, Ziqi
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Dang, Chenyuan
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Zhang, Miao
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Zhao, Bixi
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Cheng, Zhanwen
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Chen, Liming
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Zhong, Zhenfeng
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Ye, Yuhui
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Xia, Yu
|e verfasserin
|4 aut
|
| 773 |
0 |
8 |
|i Enthalten in
|t Chemical engineering journal (Lausanne, Switzerland : 1996)
|d 1999
|g 406(2021) vom: 15. Feb., Seite 126854
|w (DE-627)NLM098273531
|x 1385-8947
|7 nnas
|
| 773 |
1 |
8 |
|g volume:406
|g year:2021
|g day:15
|g month:02
|g pages:126854
|
| 856 |
4 |
0 |
|u http://dx.doi.org/10.1016/j.cej.2020.126854
|3 Volltext
|
| 912 |
|
|
|a GBV_USEFLAG_A
|
| 912 |
|
|
|a SYSFLAG_A
|
| 912 |
|
|
|a GBV_NLM
|
| 912 |
|
|
|a GBV_ILN_350
|
| 951 |
|
|
|a AR
|
| 952 |
|
|
|d 406
|j 2021
|b 15
|c 02
|h 126854
|