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231225s2020 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202002578
|2 doi
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|a pubmed24n1048.xml
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|a DE-627
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|a eng
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|a Yang, Letao
|e verfasserin
|4 aut
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|a Effective Modulation of CNS Inhibitory Microenvironment using Bioinspired Hybrid-Nanoscaffold-Based Therapeutic Interventions
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|c 2020
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|a Text
|b txt
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|a ƒaComputermedien
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|a ƒa Online-Ressource
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|a Date Completed 19.07.2021
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|a Date Revised 12.11.2023
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2020 Wiley-VCH GmbH.
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|a Central nervous system (CNS) injuries are often debilitating, and most currently have no cure. This is due to the formation of a neuroinhibitory microenvironment at injury sites, which includes neuroinflammatory signaling and non-permissive extracellular matrix (ECM) components. To address this challenge, a viscous interfacial self-assembly approach, to generate a bioinspired hybrid 3D porous nanoscaffold platform for delivering anti-inflammatory molecules and establish a favorable 3D-ECM environment for the effective suppression of the neuroinhibitory microenvironment, is developed. By tailoring the structural and biochemical properties of the 3D porous nanoscaffold, enhanced axonal growth from the dual-targeting therapeutic strategy in a human induced pluripotent stem cell (hiPSC)-based in vitro model of neuroinflammation is demonstrated. Moreover, nanoscaffold-based approaches promote significant axonal growth and functional recovery in vivo in a spinal cord injury model through a unique mechanism of anti-inflammation-based fibrotic scar reduction. Given the critical role of neuroinflammation and ECM microenvironments in neuroinhibitory signaling, the developed nanobiomaterial-based therapeutic intervention may pave a new road for treating CNS injuries
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|a Journal Article
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|a biomaterials
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|a inorganic-organic hybrid nanomaterials
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|a nanoscaffolds
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|a neural tissue engineering
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|a spinal cord injury
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|a Anti-Inflammatory Agents
|2 NLM
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|a Drug Carriers
|2 NLM
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| 700 |
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|a Conley, Brian M
|e verfasserin
|4 aut
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|a Cerqueira, Susana R
|e verfasserin
|4 aut
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|a Pongkulapa, Thanapat
|e verfasserin
|4 aut
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|a Wang, Shenqiang
|e verfasserin
|4 aut
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| 700 |
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|a Lee, Jae K
|e verfasserin
|4 aut
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| 700 |
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|a Lee, Ki-Bum
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 32(2020), 43 vom: 17. Okt., Seite e2002578
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|g volume:32
|g year:2020
|g number:43
|g day:17
|g month:10
|g pages:e2002578
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|u http://dx.doi.org/10.1002/adma.202002578
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