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231225s2020 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202003013
|2 doi
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|a pubmed24n1047.xml
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|a eng
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|a Cabanach, Pol
|e verfasserin
|4 aut
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|a Zwitterionic 3D-Printed Non-Immunogenic Stealth Microrobots
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|c 2020
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|a Text
|b txt
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|a ƒaComputermedien
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|a ƒa Online-Ressource
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|a Date Completed 14.07.2021
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|a Date Revised 12.11.2023
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2020 The Authors. Published by Wiley-VCH GmbH.
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|a Microrobots offer transformative solutions for non-invasive medical interventions due to their small size and untethered operation inside the human body. However, they must face the immune system as a natural protection mechanism against foreign threats. Here, non-immunogenic stealth zwitterionic microrobots that avoid recognition from immune cells are introduced. Fully zwitterionic photoresists are developed for two-photon polymerization 3D microprinting of hydrogel microrobots with ample functionalization: tunable mechanical properties, anti-biofouling and non-immunogenic properties, functionalization for magnetic actuation, encapsulation of biomolecules, and surface functionalization for drug delivery. Stealth microrobots avoid detection by macrophage cells of the innate immune system after exhaustive inspection (>90 hours), which has not been achieved in any microrobotic platform to date. These versatile zwitterionic materials eliminate a major roadblock in the development of biocompatible microrobots, and will serve as a toolbox of non-immunogenic materials for medical microrobot and other device technologies for bioengineering and biomedical applications
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|a Journal Article
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|a macrophages
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|a non-immunogenic properties
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|a stealth microrobots
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|a two-photon polymerization
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|a zwitterionic materials
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|a Hydrogels
|2 NLM
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|a Pena-Francesch, Abdon
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|4 aut
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|a Sheehan, Devin
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|a Bozuyuk, Ugur
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|a Yasa, Oncay
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|a Borros, Salvador
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|4 aut
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|a Sitti, Metin
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 32(2020), 42 vom: 11. Okt., Seite e2003013
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|u http://dx.doi.org/10.1002/adma.202003013
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