|
|
|
|
| LEADER |
01000caa a22002652c 4500 |
| 001 |
NLM314379312 |
| 003 |
DE-627 |
| 005 |
20250227214429.0 |
| 007 |
cr uuu---uuuuu |
| 008 |
231225s2020 xx |||||o 00| ||eng c |
| 024 |
7 |
|
|a 10.1002/adma.202004210
|2 doi
|
| 028 |
5 |
2 |
|a pubmed25n1047.xml
|
| 035 |
|
|
|a (DE-627)NLM314379312
|
| 035 |
|
|
|a (NLM)32864794
|
| 040 |
|
|
|a DE-627
|b ger
|c DE-627
|e rakwb
|
| 041 |
|
|
|a eng
|
| 100 |
1 |
|
|a Peng, Sha
|e verfasserin
|4 aut
|
| 245 |
1 |
0 |
|a Particulate Alum via Pickering Emulsion for an Enhanced COVID-19 Vaccine Adjuvant
|
| 264 |
|
1 |
|c 2020
|
| 336 |
|
|
|a Text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a ƒaComputermedien
|b c
|2 rdamedia
|
| 338 |
|
|
|a ƒa Online-Ressource
|b cr
|2 rdacarrier
|
| 500 |
|
|
|a Date Completed 19.10.2020
|
| 500 |
|
|
|a Date Revised 18.12.2020
|
| 500 |
|
|
|a published: Print-Electronic
|
| 500 |
|
|
|a Citation Status MEDLINE
|
| 520 |
|
|
|a © 2020 Wiley-VCH GmbH.
|
| 520 |
|
|
|a For rapid response against the prevailing COVID-19 (coronavirus disease 19), it is a global imperative to exploit the immunogenicity of existing formulations for safe and efficient vaccines. As the most accessible adjuvant, aluminum hydroxide (alum) is still the sole employed adjuvant in most countries. However, alum tends to attach on the membrane rather than entering the dendritic cells (DCs), leading to the absence of intracellular transfer and process of the antigens, and thus limits T-cell-mediated immunity. To address this, alum is packed on the squalene/water interphase is packed, forming an alum-stabilized Pickering emulsion (PAPE). "Inheriting" from alum and squalene, PAPE demonstrates a good biosafety profile. Intriguingly, with the dense array of alum on the oil/water interphase, PAPE not only adsorbs large quantities of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) antigens, but also harbors a higher affinity for DC uptake, which provokes the uptake and cross-presentation of the delivered antigens. Compared with alum-treated groups, more than six times higher antigen-specific antibody titer and three-fold more IFN-γ-secreting T cells are induced, indicating the potent humoral and cellular immune activations. Collectively, the data suggest that PAPE may provide potential insights toward a safe and efficient adjuvant platform for the enhanced COVID-19 vaccinations
|
| 650 |
|
4 |
|a Journal Article
|
| 650 |
|
4 |
|a COVID-19 vaccine adjuvant
|
| 650 |
|
4 |
|a Pickering emulsion
|
| 650 |
|
4 |
|a SARS-CoV-2
|
| 650 |
|
4 |
|a alum
|
| 650 |
|
4 |
|a cellular immune responses
|
| 650 |
|
7 |
|a Adjuvants, Immunologic
|2 NLM
|
| 650 |
|
7 |
|a Alum Compounds
|2 NLM
|
| 650 |
|
7 |
|a Antigens, Viral
|2 NLM
|
| 650 |
|
7 |
|a COVID-19 Vaccines
|2 NLM
|
| 650 |
|
7 |
|a Emulsions
|2 NLM
|
| 650 |
|
7 |
|a Spike Glycoprotein, Coronavirus
|2 NLM
|
| 650 |
|
7 |
|a Viral Vaccines
|2 NLM
|
| 650 |
|
7 |
|a spike protein, SARS-CoV-2
|2 NLM
|
| 650 |
|
7 |
|a aluminum sulfate
|2 NLM
|
| 650 |
|
7 |
|a 34S289N54E
|2 NLM
|
| 650 |
|
7 |
|a Interferon-gamma
|2 NLM
|
| 650 |
|
7 |
|a 82115-62-6
|2 NLM
|
| 700 |
1 |
|
|a Cao, Fengqiang
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Xia, Yufei
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Gao, Xiao-Dong
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Dai, Lianpan
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Yan, Jinghua
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Ma, Guanghui
|e verfasserin
|4 aut
|
| 773 |
0 |
8 |
|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 32(2020), 40 vom: 04. Okt., Seite e2004210
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnas
|
| 773 |
1 |
8 |
|g volume:32
|g year:2020
|g number:40
|g day:04
|g month:10
|g pages:e2004210
|
| 856 |
4 |
0 |
|u http://dx.doi.org/10.1002/adma.202004210
|3 Volltext
|
| 912 |
|
|
|a GBV_USEFLAG_A
|
| 912 |
|
|
|a SYSFLAG_A
|
| 912 |
|
|
|a GBV_NLM
|
| 912 |
|
|
|a GBV_ILN_350
|
| 951 |
|
|
|a AR
|
| 952 |
|
|
|d 32
|j 2020
|e 40
|b 04
|c 10
|h e2004210
|