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231225s2020 xx |||||o 00| ||eng c |
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|a 10.1093/jxb/eraa387
|2 doi
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|a pubmed24n1046.xml
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|a (DE-627)NLM314006842
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|a (NLM)32827041
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|a DE-627
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|e rakwb
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|a eng
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|a Liu, Fang
|e verfasserin
|4 aut
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|a Haplotype-based genome-wide association increases the predictability of leaf rust (Puccinia triticina) resistance in wheat
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|c 2020
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 14.05.2021
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|a Date Revised 14.05.2021
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|a published: Print
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|a Dryad: 10.5061/dryad.3n5tb2rf3
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|a Citation Status MEDLINE
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|a © The Author(s) 2020. Published by Oxford University Press on behalf of the Society for Experimental Biology. All rights reserved. For permissions, please email: journals.permissionsoup.com.
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|a Resistance breeding is crucial for sustainable control of wheat leaf rust and single nucleotide polymorphism (SNP)-based genome-wide association studies (GWAS) are widely used to dissect leaf rust resistance. Unfortunately, GWAS based on SNPs often explained only a small proportion of the genetic variation. We compared SNP-based GWAS with a method based on functional haplotypes (FH) considering epistasis in a comprehensive hybrid wheat mapping population composed of 133 parents plus their 1574 hybrids and characterized with 626 245 high-quality SNPs. In total, 2408 and 1 139 828 significant associations were detected in the mapping population by using SNP-based and FH-based GWAS, respectively. These associations mapped to 25 and 69 candidate regions, correspondingly. SNP-based GWAS highlighted two already-known resistance genes, Lr22a and Lr34-B, while FH-based GWAS detected associations not only on these genes but also on two additional genes, Lr10 and Lr1. As revealed by a second hybrid wheat population for independent validation, the use of detected associations from SNP-based and FH-based GWAS reached predictabilities of 11.72% and 22.86%, respectively. Therefore, FH-based GWAS is not only more powerful for detecting associations, but also improves the accuracy of marker-assisted selection compared with the SNP-based approach
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Association mapping
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|a FH-based GWAS
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|a SNP-based GWAS
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|a functional haplotype
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|a hybrid wheat
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|a independent validation
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|a leaf rust
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| 650 |
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|a predictability
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|a Jiang, Yong
|e verfasserin
|4 aut
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| 700 |
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|a Zhao, Yusheng
|e verfasserin
|4 aut
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| 700 |
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|a Schulthess, Albert W
|e verfasserin
|4 aut
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| 700 |
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|a Reif, Jochen C
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Journal of experimental botany
|d 1985
|g 71(2020), 22 vom: 31. Dez., Seite 6958-6968
|w (DE-627)NLM098182706
|x 1460-2431
|7 nnns
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| 773 |
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|g volume:71
|g year:2020
|g number:22
|g day:31
|g month:12
|g pages:6958-6968
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|u http://dx.doi.org/10.1093/jxb/eraa387
|3 Volltext
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