|
|
|
|
| LEADER |
01000caa a22002652c 4500 |
| 001 |
NLM313943044 |
| 003 |
DE-627 |
| 005 |
20250227200839.0 |
| 007 |
cr uuu---uuuuu |
| 008 |
231225s2020 xx |||||o 00| ||eng c |
| 024 |
7 |
|
|a 10.1002/adma.202004300
|2 doi
|
| 028 |
5 |
2 |
|a pubmed25n1046.xml
|
| 035 |
|
|
|a (DE-627)NLM313943044
|
| 035 |
|
|
|a (NLM)32820574
|
| 040 |
|
|
|a DE-627
|b ger
|c DE-627
|e rakwb
|
| 041 |
|
|
|a eng
|
| 100 |
1 |
|
|a Min, Sunhong
|e verfasserin
|4 aut
|
| 245 |
1 |
0 |
|a Independent Tuning of Nano-Ligand Frequency and Sequences Regulates the Adhesion and Differentiation of Stem Cells
|
| 264 |
|
1 |
|c 2020
|
| 336 |
|
|
|a Text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a ƒaComputermedien
|b c
|2 rdamedia
|
| 338 |
|
|
|a ƒa Online-Ressource
|b cr
|2 rdacarrier
|
| 500 |
|
|
|a Date Completed 08.07.2021
|
| 500 |
|
|
|a Date Revised 08.07.2021
|
| 500 |
|
|
|a published: Print-Electronic
|
| 500 |
|
|
|a Citation Status MEDLINE
|
| 520 |
|
|
|a © 2020 Wiley-VCH GmbH.
|
| 520 |
|
|
|a The native extracellular matrix (ECM) can exhibit heterogeneous nano-sequences periodically displaying ligands to regulate complex cell-material interactions in vivo. Herein, an ECM-emulating heterogeneous barcoding system, including ligand-bearing Au and ligand-free Fe nano-segments, is developed to independently present tunable frequency and sequences in nano-segments of cell-adhesive RGD ligand. Specifically, similar exposed surface areas of total Fe and Au nano-segments are designed. Fe segments are used for substrate coupling of nanobarcodes and as ligand-free nano-segments and Au segments for ligand coating while maintaining both nanoscale (local) and macroscale (total) ligand density constant in all groups. Low nano-ligand frequency in the same sequences and terminally sequenced nano-ligands at the same frequency independently facilitate focal adhesion and mechanosensing of stem cells, which are collectively effective both in vitro and in vivo, thereby inducing stem cell differentiation. The Fe/RGD-Au nanobarcode implants exhibit high stability and no local and systemic toxicity in various tissues and organs in vivo. This work sheds novel insight into designing biomaterials with heterogeneous nano-ligand sequences at terminal sides and/or low frequency to facilitate cellular adhesion. Tuning the electrodeposition conditions can allow synthesis of unlimited combinations of ligand nano-sequences and frequencies, magnetic elements, and bioactive ligands to remotely regulate numerous host cells in vivo
|
| 650 |
|
4 |
|a Journal Article
|
| 650 |
|
4 |
|a cell adhesion
|
| 650 |
|
4 |
|a nano-ligand frequencies
|
| 650 |
|
4 |
|a nano-ligand sequences
|
| 650 |
|
4 |
|a stem cell differentiation
|
| 650 |
|
4 |
|a unlimited nanobarcode tunability
|
| 650 |
|
7 |
|a Ligands
|2 NLM
|
| 650 |
|
7 |
|a Oligopeptides
|2 NLM
|
| 650 |
|
7 |
|a Gold
|2 NLM
|
| 650 |
|
7 |
|a 7440-57-5
|2 NLM
|
| 650 |
|
7 |
|a arginyl-glycyl-aspartic acid
|2 NLM
|
| 650 |
|
7 |
|a 78VO7F77PN
|2 NLM
|
| 650 |
|
7 |
|a Iron
|2 NLM
|
| 650 |
|
7 |
|a E1UOL152H7
|2 NLM
|
| 700 |
1 |
|
|a Jeon, Yoo Sang
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Jung, Hee Joon
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Khatua, Chandra
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Li, Na
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Bae, Gunhyu
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Choi, Hyojun
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Hong, Hyunsik
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Shin, Jeong Eun
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Ko, Min Jun
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Ko, Han Seok
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Jun, Indong
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Fu, Hong En
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Kim, Seung Hyun
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Thangam, Ramar
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Song, Jae-Jun
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Dravid, Vinayak P
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Kim, Young Keun
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Kang, Heemin
|e verfasserin
|4 aut
|
| 773 |
0 |
8 |
|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 32(2020), 40 vom: 16. Okt., Seite e2004300
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnas
|
| 773 |
1 |
8 |
|g volume:32
|g year:2020
|g number:40
|g day:16
|g month:10
|g pages:e2004300
|
| 856 |
4 |
0 |
|u http://dx.doi.org/10.1002/adma.202004300
|3 Volltext
|
| 912 |
|
|
|a GBV_USEFLAG_A
|
| 912 |
|
|
|a SYSFLAG_A
|
| 912 |
|
|
|a GBV_NLM
|
| 912 |
|
|
|a GBV_ILN_350
|
| 951 |
|
|
|a AR
|
| 952 |
|
|
|d 32
|j 2020
|e 40
|b 16
|c 10
|h e2004300
|