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231225s2020 xx |||||o 00| ||eng c |
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|a 10.1021/acs.langmuir.0c01512
|2 doi
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|a pubmed24n1488.xml
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|a eng
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| 100 |
1 |
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|a Szczęch, Marta
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Nafion-Based Nanocarriers for Fluorine Magnetic Resonance Imaging
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| 264 |
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|c 2020
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|a ƒa Online-Ressource
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|a Date Completed 29.09.2020
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|a Date Revised 01.08.2024
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|a published: Print-Electronic
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|a Citation Status PubMed-not-MEDLINE
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|a The aim of our study was to develop a novel method for nanocarriers' preparation as a fluorine magnetic resonance imaging (19F MRI)-detectable drug delivery system. The novelty of the proposed approach is based on the application of fluorinated polyelectrolyte Nafion as a contrast agent since typical MRI contrast agents are based on paramagnetic gadolinium or ferro/superparamagnetic iron oxide compounds. An advantage of using an 19F-based tracer comes from the fact that the 19F image is detected at a different resonance frequency than the 1H image. In addition, the close to zero natural concentration of 19F nuclei in the human body makes fluorine atoms a promising MRI marker without any natural background signal. That creates the opportunity to localize and identify only exogenous fluorinated compounds with 100% specificity. The nanocarriers were formed by the deposition of polyelectrolytes on nanoemulsion droplets via the layer-by-layer technique with the saturation approach. The polyelectrolyte multilayer shell was composed of Nafion, the fluorinated ionic polymer used for labeling by 19F nuclei, and poly-l-lysine (PLL). The surface of such prepared nanocarriers was further pegylated by adsorption of pegylated polyanion, poly-l-glutamic acid (PGA). The 19F MRI-detectable hydrophobic nanocarriers with an average size of 170 nm and a sufficient signal-to-noise ratio have been developed and optimized to be used for passive tumor targeting and drug delivery
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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| 700 |
1 |
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|a Łopuszyńska, Natalia
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Tomal, Wiktoria
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Jasiński, Krzysztof
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Węglarz, Władysław P
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Warszyński, Piotr
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Szczepanowicz, Krzysztof
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1999
|g 36(2020), 32 vom: 18. Aug., Seite 9534-9539
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
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|g volume:36
|g year:2020
|g number:32
|g day:18
|g month:08
|g pages:9534-9539
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|u http://dx.doi.org/10.1021/acs.langmuir.0c01512
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