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231225s2020 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202001108
|2 doi
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|a pubmed24n1042.xml
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|a (DE-627)NLM312765452
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|a (NLM)32700437
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|a DE-627
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|e rakwb
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|a eng
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| 100 |
1 |
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|a Shen, Wei
|e verfasserin
|4 aut
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| 245 |
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|a Antineoplastic Drug-Free Anticancer Strategy Enabled by Host-Defense-Peptides-Mimicking Synthetic Polypeptides
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|c 2020
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 20.08.2021
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|a Date Revised 20.08.2021
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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|a An antineoplastic drug-free anticancer strategy enabled by host defense peptides (HDPs)-mimicking synthetic polypeptides is reported. The polypeptide exhibits a broad spectrum of anticancer activity in 12 cancer cell lines, including drug-resistant and highly metastatic tumor cells. Detailed mechanistic studies reveal that the cationic anticancer polypeptide (ACPP) can directly induce rapid necrosis of cancer cells within minutes through a membrane-lytic mechanism. Moreover, a pH-sensitive zwitterionic derivative of ACPP (DA-ACPP) is prepared for in vivo application. DA-ACPP shows negligible hemolysis under neutral physiological conditions, and can be converted back to ACPP in slightly acidic tumor environments, resulting in selective killing of cancer cells. Consequently, DA-ACPP shows an effective inhibition of tumor growth in both 4T1 orthotopic breast tumor models and B16-F10 melanoma pulmonary metastatic models. Overall, these findings demonstrate that synthetic HDPs-mimicking polypeptides represent safe and effective antineoplastic agents, which sheds new light on the development of drug-free synthetic polymers for cancer therapy
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|a Journal Article
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|a anticancer
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|a membrane-lytic strategies
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|a pH-sensitivity
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| 650 |
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4 |
|a polymer therapeutics
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| 650 |
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|a polypeptides
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| 650 |
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|a Antimicrobial Cationic Peptides
|2 NLM
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| 650 |
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|a Antineoplastic Agents
|2 NLM
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| 650 |
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|a Peptidomimetics
|2 NLM
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| 700 |
1 |
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|a Zhang, Yu
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wan, Pengqi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a An, Lin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Peng
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Xiao, Chunsheng
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chen, Xuesi
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 32(2020), 36 vom: 15. Sept., Seite e2001108
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
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| 773 |
1 |
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|g volume:32
|g year:2020
|g number:36
|g day:15
|g month:09
|g pages:e2001108
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| 856 |
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|u http://dx.doi.org/10.1002/adma.202001108
|3 Volltext
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