Influence of External NaCl Salt on Membrane Rigidity of Neutral DOPC Vesicles

Sodium chloride (NaCl) is a very common molecule in biotic and abiotic aqueous environments. In both cases, variation of ionic strength is inevitable. In addition to the osmotic variation posed by such perturbations, the question of whether the interactions of monovalent ions Na+ and Cl-, especially...

Ausführliche Beschreibung

Bibliographische Detailangaben
Veröffentlicht in:Langmuir : the ACS journal of surfaces and colloids. - 1992. - 36(2020), 32 vom: 18. Aug., Seite 9356-9367
1. Verfasser: De Mel, Judith U (VerfasserIn)
Weitere Verfasser: Gupta, Sudipta, Perera, Rasangi M, Ngo, Ly, Zolnierczuk, Piotr, Bleuel, Markus, Pingali, Sai Venkatesh, Schneider, Gerald J
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2020
Zugriff auf das übergeordnete Werk:Langmuir : the ACS journal of surfaces and colloids
Schlagworte:Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S. Lipid Bilayers Phosphatidylcholines Sodium Chloride 451W47IQ8X 1,2-oleoylphosphatidylcholine EDS2L3ODLV
LEADER 01000naa a22002652 4500
001 NLM312493940
003 DE-627
005 20231225144530.0
007 cr uuu---uuuuu
008 231225s2020 xx |||||o 00| ||eng c
024 7 |a 10.1021/acs.langmuir.0c01004  |2 doi 
028 5 2 |a pubmed24n1041.xml 
035 |a (DE-627)NLM312493940 
035 |a (NLM)32672981 
040 |a DE-627  |b ger  |c DE-627  |e rakwb 
041 |a eng 
100 1 |a De Mel, Judith U  |e verfasserin  |4 aut 
245 1 0 |a Influence of External NaCl Salt on Membrane Rigidity of Neutral DOPC Vesicles 
264 1 |c 2020 
336 |a Text  |b txt  |2 rdacontent 
337 |a ƒaComputermedien  |b c  |2 rdamedia 
338 |a ƒa Online-Ressource  |b cr  |2 rdacarrier 
500 |a Date Completed 21.06.2021 
500 |a Date Revised 21.06.2021 
500 |a published: Print-Electronic 
500 |a Citation Status MEDLINE 
520 |a Sodium chloride (NaCl) is a very common molecule in biotic and abiotic aqueous environments. In both cases, variation of ionic strength is inevitable. In addition to the osmotic variation posed by such perturbations, the question of whether the interactions of monovalent ions Na+ and Cl-, especially with the neutral head groups of phospholipid membranes are impactful enough to change the membrane rigidity, is still not entirely understood. We investigated the dynamics of 1,2-di-(octadecenoyl)-sn-glycero-3-phosphocholine (DOPC) vesicles with zwitterionic neutral head groups in the fluid phase with increasing external salt concentration. At higher salt concentrations, we observe an increase in bending rigidity from neutron spin echo (NSE) spectroscopy and an increase in bilayer thickness from small-angle X-ray scattering (SAXS). We compared different models to distinguish membrane undulations, lipid tail motions, and the translational diffusion of the vesicles. All of the models indicate an increase in bending rigidity by a factor of 1.3-3.6. We demonstrate that even down to t > 10 ns and for Q > 0.07 Å-1, the observed NSE relaxation spectra are influenced by translational diffusion of the vesicles. For t < 5 ns, the lipid tail motion dominates the intermediate dynamic structure factor. As the salt concentration increases, this contribution diminishes. We introduced a time-dependent analysis for the bending rigidity that highlights only a limited Zilman-Granek time window in which the rigidity is physically meaningful 
650 4 |a Journal Article 
650 4 |a Research Support, N.I.H., Extramural 
650 4 |a Research Support, U.S. Gov't, Non-P.H.S. 
650 7 |a Lipid Bilayers  |2 NLM 
650 7 |a Phosphatidylcholines  |2 NLM 
650 7 |a Sodium Chloride  |2 NLM 
650 7 |a 451W47IQ8X  |2 NLM 
650 7 |a 1,2-oleoylphosphatidylcholine  |2 NLM 
650 7 |a EDS2L3ODLV  |2 NLM 
700 1 |a Gupta, Sudipta  |e verfasserin  |4 aut 
700 1 |a Perera, Rasangi M  |e verfasserin  |4 aut 
700 1 |a Ngo, Ly  |e verfasserin  |4 aut 
700 1 |a Zolnierczuk, Piotr  |e verfasserin  |4 aut 
700 1 |a Bleuel, Markus  |e verfasserin  |4 aut 
700 1 |a Pingali, Sai Venkatesh  |e verfasserin  |4 aut 
700 1 |a Schneider, Gerald J  |e verfasserin  |4 aut 
773 0 8 |i Enthalten in  |t Langmuir : the ACS journal of surfaces and colloids  |d 1992  |g 36(2020), 32 vom: 18. Aug., Seite 9356-9367  |w (DE-627)NLM098181009  |x 1520-5827  |7 nnns 
773 1 8 |g volume:36  |g year:2020  |g number:32  |g day:18  |g month:08  |g pages:9356-9367 
856 4 0 |u http://dx.doi.org/10.1021/acs.langmuir.0c01004  |3 Volltext 
912 |a GBV_USEFLAG_A 
912 |a SYSFLAG_A 
912 |a GBV_NLM 
912 |a GBV_ILN_22 
912 |a GBV_ILN_350 
912 |a GBV_ILN_721 
951 |a AR 
952 |d 36  |j 2020  |e 32  |b 18  |c 08  |h 9356-9367