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231225s2020 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2020.108515
|2 doi
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|a pubmed24n1039.xml
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|a DE-627
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|a eng
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| 100 |
1 |
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|a Damoiseaux, Jan
|e verfasserin
|4 aut
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| 245 |
1 |
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|a The IL-2 - IL-2 receptor pathway in health and disease
|b The role of the soluble IL-2 receptor
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|c 2020
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 17.05.2021
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|a Date Revised 17.05.2021
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2020 The Author. Published by Elsevier Inc. All rights reserved.
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|a The interleukin (IL)-2 - IL-2 receptor (IL-2R) pathway is important in immunity, but is also involved in maintenance of self-tolerance. This paradox is further complicated by shedding of the IL-2Rα chain, revealing soluble (s)IL-2R. Binding of IL-2 to sIL-2R may either reduce or enhance responses depending on the target cell being involved in immunity or self-tolerance. Since sIL-2R levels are increasingly measured in clinical practice, it is detrimental for clinical interpretation to understand the possible functional impact of IL-2R shedding. In this review the role of the IL-2 - IL-2R pathway is explored and the conflicting results on the function of sIL-2R are summarized. Finally, the added value of measuring sIL-2R in different types of diseases is being elaborated upon in terms of diagnosis, follow-up, and prognosis. Adequate interpretation of results is hampered by the apparent gap in our knowledge about the functional role of sIL-2R in immunity and tolerance
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|a Journal Article
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|a Review
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| 650 |
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4 |
|a CD25
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| 650 |
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4 |
|a Immunity
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| 650 |
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4 |
|a Interleukin 2
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| 650 |
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4 |
|a Interleukin 2 receptor
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| 650 |
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4 |
|a Tolerance
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| 650 |
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4 |
|a soluble IL-2R
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| 650 |
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|a Interleukin-2
|2 NLM
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| 650 |
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|a Receptors, Interleukin-2
|2 NLM
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| 773 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 218(2020) vom: 10. Sept., Seite 108515
|w (DE-627)NLM098196855
|x 1521-7035
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| 773 |
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|g volume:218
|g year:2020
|g day:10
|g month:09
|g pages:108515
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| 856 |
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|u http://dx.doi.org/10.1016/j.clim.2020.108515
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