Relationship between Urinary Alzheimer-Associated Neuronal Thread Protein and Apolipoprotein Epsilon 4 Allele in the Cognitively Normal Population

Relationship between Urinary Alzheimer-Associated Neuronal Thread Protein and Apolipoprotein Epsilon 4 Allele in the Cognitively Normal Population

Copyright © 2020 Yuxia Li et al.

Détails bibliographiques
Publié dans:Neural plasticity. - 1998. - 2020(2020) vom: 19., Seite 9742138
Auteur principal: Li, Yuxia (Auteur)
Autres auteurs: Kang, Meimei, Sheng, Can, Chen, Guanqun, Li, Taoran, Wang, Jun, Cai, Yanning, Wang, Rong, Han, Ying
Format: Article en ligne
Langue:English
Publié: 2020
Accès à la collection:Neural plasticity
Sujets:Journal Article Research Support, Non-U.S. Gov't AD7c-NTP protein, human Apolipoprotein E4 Nerve Tissue Proteins
Description
Résumé:Copyright © 2020 Yuxia Li et al.
We investigated the relationship between urinary Alzheimer-associated neuronal thread protein (AD7c-NTP) levels and apolipoprotein epsilon 4 (ApoE ɛ4) alleles, as well as other factors that cause cognitive decline, in the cognitively normal population. We recruited 329 cognitively normal right-handed Han Chinese subjects who completed ApoE gene testing and urinary AD7c-NTP testing. There was no significant difference in urinary AD7c-NTP levels between the normal control and subjective cognitive decline groups. Urinary AD7c-NTP levels were significantly higher in subjects with ApoE ɛ3/4 and 4/4 [0.6074 (0.6541) ng/mL] than in subjects without ApoE ɛ4 [0.4368 (0.3392) ng/mL and 0.5287 (0.3656) ng/mL], and urinary AD7c-NTP levels positively correlated with ApoE genotype grade (r = 0.165, p = 0.003). There were significant differences in urinary AD7c-NTP levels between subjects with and without a history of coronary heart disease or diabetes. Urinary AD7c-NTP levels were not related to years of education, nature of work, family history of dementia, a history of hypertension, stroke, anemia, or thyroid dysfunction. Urinary AD7c-NTP levels were positively correlated with ApoE grade in the cognitively normal population. The relationship between risk factors of cognitive decline and urinary AD7c-NTP levels provides a new way for us to understand AD and urinary AD7c-NTP
Description:Date Completed 30.06.2021
Date Revised 30.06.2021
published: Electronic-eCollection
Citation Status MEDLINE
ISSN:1687-5443
DOI:10.1155/2020/9742138