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NLM311567924 |
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DE-627 |
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20240922233815.0 |
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cr uuu---uuuuu |
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231225s2020 xx |||||o 00| ||eng c |
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7 |
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|a 10.1002/adma.202002611
|2 doi
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|a pubmed24n1543.xml
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|a (DE-627)NLM311567924
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|a (NLM)32578337
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Hu, Jingjie
|e verfasserin
|4 aut
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| 245 |
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|a Bioactive-Tissue-Derived Nanocomposite Hydrogel for Permanent Arterial Embolization and Enhanced Vascular Healing
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|c 2020
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 10.06.2021
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|a Date Revised 22.09.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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|a Transcatheter embolization is a minimally invasive procedure that uses embolic agents to intentionally block diseased or injured blood vessels for therapeutic purposes. Embolic agents in clinical practice are limited by recanalization, risk of non-target embolization, failure in coagulopathic patients, high cost, and toxicity. Here, a decellularized cardiac extracellular matrix (ECM)-based nanocomposite hydrogel is developed to provide superior mechanical stability, catheter injectability, retrievability, antibacterial properties, and biological activity to prevent recanalization. The embolic efficacy of the shear-thinning ECM-based hydrogel is shown in a porcine survival model of embolization in the iliac artery and the renal artery. The ECM-based hydrogel promotes arterial vessel wall remodeling and a fibroinflammatory response while undergoing significant biodegradation such that only 25% of the embolic material remains at 14 days. With its unprecedented proregenerative, antibacterial properties coupled with favorable mechanical properties, and its superior performance in anticoagulated blood, the ECM-based hydrogel has the potential to be a next-generation biofunctional embolic agent that can successfully treat a wide range of vascular diseases
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|a Journal Article
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|a decellularized extracellular matrix
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|a embolization
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|a hybrid nanocomposite hydrogels
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| 650 |
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4 |
|a transcatheter delivery
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| 650 |
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4 |
|a vascular remodeling
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| 650 |
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|a Biocompatible Materials
|2 NLM
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| 650 |
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|a Hydrogels
|2 NLM
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| 700 |
1 |
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|a Altun, Izzet
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Zefu
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Albadawi, Hassan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Salomao, Marcela A
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Mayer, Joseph L
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Hemachandra, L P Madhubhani P
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Rehman, Suliman
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Oklu, Rahmi
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 32(2020), 33 vom: 24. Aug., Seite e2002611
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
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|g volume:32
|g year:2020
|g number:33
|g day:24
|g month:08
|g pages:e2002611
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| 856 |
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|u http://dx.doi.org/10.1002/adma.202002611
|3 Volltext
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