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231225s2020 xx |||||o 00| ||eng c |
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|a 10.1016/j.plantsci.2020.110505
|2 doi
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|a pubmed24n1038.xml
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|a (DE-627)NLM311420893
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|a (PII)S0168-9452(20)30108-4
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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|a Joshna, Chris R
|e verfasserin
|4 aut
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|a Plant PUF RNA-binding proteins
|b A wealth of diversity for post-transcriptional gene regulation
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|c 2020
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 27.01.2021
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|a Date Revised 27.01.2021
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2020 Elsevier B.V. All rights reserved.
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|a PUF proteins are a conserved group of sequence-specific RNA-binding proteins that typically function to negatively regulate mRNA stability and translation. PUFs are well characterized at the molecular, structural and functional levels in Drosophila, Caenorhabditis elegans, budding yeast and human systems. Although usually encoded by small gene families, PUFs are over-represented in the plant genome, with up to 36 genes identified in a single species. PUF gene expansion in plants has resulted in extensive variability in gene expression patterns, diversity in predicted RNA-binding domain structure, and novel combinations of key amino acids involved in modular nucleotide binding. Reports on the characterization of plant PUF structure and function continue to expand, and include RNA target identification, subcellular distribution, crystal structure, and molecular mechanisms. Arabidopsis PUF mutant analysis has provided insight into biological function, and has identified roles related to development and environmental stress tolerance. The diversity of plant PUFs implies an extensive role for this family of proteins in post-transcriptional gene regulation. This diversity also holds the potential for providing novel RNA-binding domains that could be engineered to produce designer PUFs to alter the metabolism of target RNAs in the cell
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|a Journal Article
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|a Review
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|a APUM
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|a PUF protein family
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|a Post-transcriptional control
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|a Protein engineering
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|a RNA-binding protein
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|a RNA, Plant
|2 NLM
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|a RNA-Binding Proteins
|2 NLM
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|a Saha, Pritha
|e verfasserin
|4 aut
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|a Atugala, Dilini
|e verfasserin
|4 aut
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|a Chua, Gordon
|e verfasserin
|4 aut
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| 700 |
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|a Muench, Douglas G
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Plant science : an international journal of experimental plant biology
|d 1985
|g 297(2020) vom: 20. Aug., Seite 110505
|w (DE-627)NLM098174193
|x 1873-2259
|7 nnns
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| 773 |
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|g volume:297
|g year:2020
|g day:20
|g month:08
|g pages:110505
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|u http://dx.doi.org/10.1016/j.plantsci.2020.110505
|3 Volltext
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