|
|
|
|
| LEADER |
01000naa a22002652 4500 |
| 001 |
NLM311304605 |
| 003 |
DE-627 |
| 005 |
20231225141951.0 |
| 007 |
cr uuu---uuuuu |
| 008 |
231225s2020 xx |||||o 00| ||eng c |
| 024 |
7 |
|
|a 10.1021/acs.langmuir.0c01002
|2 doi
|
| 028 |
5 |
2 |
|a pubmed24n1037.xml
|
| 035 |
|
|
|a (DE-627)NLM311304605
|
| 035 |
|
|
|a (NLM)32551689
|
| 040 |
|
|
|a DE-627
|b ger
|c DE-627
|e rakwb
|
| 041 |
|
|
|a eng
|
| 100 |
1 |
|
|a Bassir Kazeruni, Neda M
|e verfasserin
|4 aut
|
| 245 |
1 |
0 |
|a Microtubule Detachment in Gliding Motility Assays Limits the Performance of Kinesin-Driven Molecular Shuttles
|
| 264 |
|
1 |
|c 2020
|
| 336 |
|
|
|a Text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a ƒaComputermedien
|b c
|2 rdamedia
|
| 338 |
|
|
|a ƒa Online-Ressource
|b cr
|2 rdacarrier
|
| 500 |
|
|
|a Date Completed 21.06.2021
|
| 500 |
|
|
|a Date Revised 04.12.2021
|
| 500 |
|
|
|a published: Print-Electronic
|
| 500 |
|
|
|a ErratumIn: Langmuir. 2020 Dec 8;36(48):14899. - PMID 33237774
|
| 500 |
|
|
|a Citation Status MEDLINE
|
| 520 |
|
|
|a The creation of complex active nanosystems integrating cytoskeletal filaments propelled by surface-adhered motor proteins often relies on the filaments' ability to glide over up to meter-long distances. While theoretical considerations support this ability, we show that microtubule detachment (either spontaneous or triggered by a microtubule crossing event) is a non-negligible phenomenon that has been overlooked until now. The average gliding distance before spontaneous detachment was measured to be 30 ± 10 mm for a functional kinesin-1 density of 500 μm-2 and 9 ± 4 mm for a functional kinesin-1 density of 100 μm-2 at 1 mM ATP. Even microtubules longer than 3 μm detached, suggesting that spontaneous detachment is not caused by the stochastic absence of motors or their stochastic release due to a limited run length
|
| 650 |
|
4 |
|a Journal Article
|
| 650 |
|
4 |
|a Research Support, U.S. Gov't, Non-P.H.S.
|
| 650 |
|
7 |
|a Kinesins
|2 NLM
|
| 650 |
|
7 |
|a EC 3.6.4.4
|2 NLM
|
| 700 |
1 |
|
|a Rodriguez, Juan B
|c 3rd
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Saper, Gadiel
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Hess, Henry
|e verfasserin
|4 aut
|
| 773 |
0 |
8 |
|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 36(2020), 27 vom: 14. Juli, Seite 7901-7907
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
|
| 773 |
1 |
8 |
|g volume:36
|g year:2020
|g number:27
|g day:14
|g month:07
|g pages:7901-7907
|
| 856 |
4 |
0 |
|u http://dx.doi.org/10.1021/acs.langmuir.0c01002
|3 Volltext
|
| 912 |
|
|
|a GBV_USEFLAG_A
|
| 912 |
|
|
|a SYSFLAG_A
|
| 912 |
|
|
|a GBV_NLM
|
| 912 |
|
|
|a GBV_ILN_22
|
| 912 |
|
|
|a GBV_ILN_350
|
| 912 |
|
|
|a GBV_ILN_721
|
| 951 |
|
|
|a AR
|
| 952 |
|
|
|d 36
|j 2020
|e 27
|b 14
|c 07
|h 7901-7907
|