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231225s2020 xx |||||o 00| ||eng c |
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|a 10.1021/acs.langmuir.0c01002
|2 doi
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|a pubmed24n1037.xml
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|a eng
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|a Bassir Kazeruni, Neda M
|e verfasserin
|4 aut
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| 245 |
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|a Microtubule Detachment in Gliding Motility Assays Limits the Performance of Kinesin-Driven Molecular Shuttles
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|c 2020
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|a Date Completed 21.06.2021
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|a Date Revised 04.12.2021
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|a published: Print-Electronic
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|a ErratumIn: Langmuir. 2020 Dec 8;36(48):14899. - PMID 33237774
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|a Citation Status MEDLINE
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|a The creation of complex active nanosystems integrating cytoskeletal filaments propelled by surface-adhered motor proteins often relies on the filaments' ability to glide over up to meter-long distances. While theoretical considerations support this ability, we show that microtubule detachment (either spontaneous or triggered by a microtubule crossing event) is a non-negligible phenomenon that has been overlooked until now. The average gliding distance before spontaneous detachment was measured to be 30 ± 10 mm for a functional kinesin-1 density of 500 μm-2 and 9 ± 4 mm for a functional kinesin-1 density of 100 μm-2 at 1 mM ATP. Even microtubules longer than 3 μm detached, suggesting that spontaneous detachment is not caused by the stochastic absence of motors or their stochastic release due to a limited run length
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|a Journal Article
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|a Research Support, U.S. Gov't, Non-P.H.S.
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|a Kinesins
|2 NLM
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| 650 |
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|a EC 3.6.4.4
|2 NLM
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| 700 |
1 |
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|a Rodriguez, Juan B
|c 3rd
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Saper, Gadiel
|e verfasserin
|4 aut
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|a Hess, Henry
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1999
|g 36(2020), 27 vom: 14. Juli, Seite 7901-7907
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|x 1520-5827
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|g volume:36
|g year:2020
|g number:27
|g day:14
|g month:07
|g pages:7901-7907
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|u http://dx.doi.org/10.1021/acs.langmuir.0c01002
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