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231225s2020 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2020.108498
|2 doi
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|a pubmed24n1244.xml
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|a (DE-627)NLM31110486X
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|a (NLM)32531345
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|a (PII)S1521-6616(20)30156-X
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Frangieh, Michael
|e verfasserin
|4 aut
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| 245 |
1 |
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|a IL-27
|b An endogenous constitutive repressor of human monocytes
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|c 2020
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 01.02.2021
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|a Date Revised 31.12.2023
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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| 520 |
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|a Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.
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|a Interleukin (IL)-27 is a pleiotropic cytokine that initially was described as being pro-inflammatory and an inducer of T helper (Th)1 cells. In contrast, it has also been described as an anti-inflammatory cytokine in that it suppresses pro-inflammatory Th17 cells and induces anti-inflammatory IL-10 producing T regulatory (Tr)1 cells. While the majority of studies have been focused on the effects of IL-27 on T cells, human antigen-presenting cells express high levels of the IL-27 receptor ex vivo, in addition to being the major producer of IL-27. We report here that human monocytes are repressed by endogenous IL-27, in that the addition of an anti-IL-27 neutralizing antibody increases the production of pro-inflammatory cytokines ex vivo. We observed that neutralizing monocyte-derived IL-27 leads to increased IL-17A production by CD4+ T cells and a down-regulation of the IL-17 modulating ectonucleotidase CD39 on monocytes. The locus that contains the IL27 gene has been linked to susceptibility for type 1 diabetes (T1D). Interestingly, ex vivo monocytes from subjects with T1D produce more IL-27 suggesting this upregulation of IL-27 acts as a negative feedback loop to attempt to counterbalance the pro-inflammatory immune response in the disease state. In summary, we provide evidence that IL-27 is an endogenous regulator of human monocytes and has consequences on CD4+ T cell phenotype, particularly Th17 cells
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|a Journal Article
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|a Research Support, N.I.H., Extramural
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| 650 |
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|a Research Support, Non-U.S. Gov't
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| 650 |
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|a Autoimmunity
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| 650 |
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|a IL-27
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| 650 |
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|a Monocytes
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| 650 |
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4 |
|a T1D
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| 650 |
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|a Th17 cells
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| 650 |
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|a IL17A protein, human
|2 NLM
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| 650 |
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|a Interleukin-17
|2 NLM
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| 650 |
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7 |
|a Interleukins
|2 NLM
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| 650 |
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|a MYDGF protein, human
|2 NLM
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| 700 |
1 |
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|a McHenry, Allison
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Phillips, Roxanne
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ye, Chun
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Bernier, Angelina
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Laffel, Lori
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Elyaman, Wassim
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Bradshaw, Elizabeth M
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 217(2020) vom: 22. Aug., Seite 108498
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
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|g volume:217
|g year:2020
|g day:22
|g month:08
|g pages:108498
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| 856 |
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|u http://dx.doi.org/10.1016/j.clim.2020.108498
|3 Volltext
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|a GBV_ILN_350
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|a AR
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|d 217
|j 2020
|b 22
|c 08
|h 108498
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