Epitaxially Strained CeO2 /Mn3 O4 Nanocrystals as an Enhanced Antioxidant for Radioprotection

Epitaxially Strained CeO2 /Mn3 O4 Nanocrystals as an Enhanced Antioxidant for Radioprotection

© 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 32(2020), 31 vom: 15. Aug., Seite e2001566
1. Verfasser: Han, Sang Ihn (VerfasserIn)
Weitere Verfasser: Lee, Sang-Woo, Cho, Min Gee, Yoo, Ji Mun, Oh, Myoung Hwan, Jeong, Beomgyun, Kim, Dokyoon, Park, Ok Kyu, Kim, Junchul, Namkoong, Eun, Jo, Jinwoung, Lee, Nohyun, Lim, Chaehong, Soh, Min, Sung, Yung-Eun, Yoo, Jongman, Park, Kyungpyo, Hyeon, Taeghwan
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2020
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article acute radiation syndrome heterostructured nanocrystals lattice strain radioprotectants reactive oxygen species Antioxidants Ki-67 Antigen Manganese Compounds Oxides mehr... Radiation-Protective Agents Reactive Oxygen Species Cerium 30K4522N6T ceric oxide 619G5K328Y manganese oxide 64J2OA7MH3
Beschreibung
Zusammenfassung:© 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Nanomaterials with antioxidant properties are promising for treating reactive oxygen species (ROS)-related diseases. However, maintaining efficacy at low doses to minimize toxicity is a critical for clinical applications. Tuning the surface strain of metallic nanoparticles can enhance catalytic reactivity, which has rarely been demonstrated in metal oxide nanomaterials. Here, it is shown that inducing surface strains of CeO2 /Mn3 O4 nanocrystals produces highly catalytic antioxidants that can protect tissue-resident stem cells from irradiation-induced ROS damage. Manganese ions deposited on the surface of cerium oxide (CeO2 ) nanocrystals form strained layers of manganese oxide (Mn3 O4 ) islands, increasing the number of oxygen vacancies. CeO2 /Mn3 O4 nanocrystals show better catalytic activity than CeO2 or Mn3 O4 alone and can protect the regenerative capabilities of intestinal stem cells in an organoid model after a lethal dose of irradiation. A small amount of the nanocrystals prevents acute radiation syndrome and increases the survival rate of mice treated with a lethal dose of total body irradiation
Beschreibung:Date Completed 01.06.2021
Date Revised 01.06.2021
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-4095
DOI:10.1002/adma.202001566