CpG-creating mutations are costly in many human viruses

Bibliographische Detailangaben
Veröffentlicht in:	Evolutionary ecology. - 1998. - 34(2020), 3 vom: 10., Seite 339-359
1. Verfasser:	Caudill, Victoria R (VerfasserIn)
Weitere Verfasser:	Qin, Sarina, Winstead, Ryan, Kaur, Jasmeen, Tisthammer, Kaho, Pineda, E Geo, Solis, Caroline, Cobey, Sarah, Bedford, Trevor, Carja, Oana, Eggo, Rosalind M, Koelle, Katia, Lythgoe, Katrina, Regoes, Roland, Roy, Scott, Allen, Nicole, Aviles, Milo, Baker, Brittany A, Bauer, William, Bermudez, Shannel, Carlson, Corey, Castellanos, Edgar, Catalan, Francisca L, Chemel, Angeline Katia, Elliot, Jacob, Evans, Dwayne, Fiutek, Natalie, Fryer, Emily, Goodfellow, Samuel Melvin, Hecht, Mordecai, Hopp, Kellen, Hopson, E Deshawn Jr, Jaberi, Amirhossein, Kinney, Christen, Lao, Derek, Le, Adrienne, Lo, Jacky, Lopez, Alejandro G, López, Andrea, Lorenzo, Fernando G, Luu, Gordon T, Mahoney, Andrew R, Melton, Rebecca L, Nascimento, Gabriela Do, Pradhananga, Anjani, Rodrigues, Nicole S, Shieh, Annie, Sims, Jasmine, Singh, Rima, Sulaeman, Hasan, Thu, Ricky, Tran, Krystal, Tran, Livia, Winters, Elizabeth J, Wong, Albert, Pennings, Pleuni S
Format:	Online-Aufsatz
Sprache:	English
Veröffentlicht:	2020
Zugriff auf das übergeordnete Werk:	Evolutionary ecology
Schlagworte:	Journal Article CpG sites Fitness costs Mutations Viruses

Beschreibung
Zusammenfassung:	© The Author(s) 2020. Mutations can occur throughout the virus genome and may be beneficial, neutral or deleterious. We are interested in mutations that yield a C next to a G, producing CpG sites. CpG sites are rare in eukaryotic and viral genomes. For the eukaryotes, it is thought that CpG sites are rare because they are prone to mutation when methylated. In viruses, we know less about why CpG sites are rare. A previous study in HIV suggested that CpG-creating transition mutations are more costly than similar non-CpG-creating mutations. To determine if this is the case in other viruses, we analyzed the allele frequencies of CpG-creating and non-CpG-creating mutations across various strains, subtypes, and genes of viruses using existing data obtained from Genbank, HIV Databases, and Virus Pathogen Resource. Our results suggest that CpG sites are indeed costly for most viruses. By understanding the cost of CpG sites, we can obtain further insights into the evolution and adaptation of viruses
Beschreibung:	Date Revised 04.09.2024 published: Print-Electronic Citation Status PubMed-not-MEDLINE
ISSN:	0269-7653
DOI:	10.1007/s10682-020-10039-z