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231225s2020 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2020.108484
|2 doi
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|a pubmed25n1035.xml
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|a (DE-627)NLM310654963
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|a (NLM)32485239
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|a (PII)S1521-6616(20)30246-1
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Fischer, Jonas
|e verfasserin
|4 aut
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| 245 |
1 |
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|a IL-21+ CD4+ T helper cells co-expressing IFN-γ and TNF-α accumulate in the joints of antinuclear antibody positive patients with juvenile idiopathic arthritis
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|c 2020
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 01.02.2021
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|a Date Revised 03.01.2025
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2020 Elsevier Inc. All rights reserved.
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|a Juvenile Idiopathic Arthritis (JIA) is currently classified into seven subgroups. Recently, antinuclear antibody (ANA) positive JIA patients were suggested to encompass a clinically homogenous new subgroup. CD4+ T helper (Th) cells play an essential role in JIA pathogenesis. Herein, we analyzed cytokine expression in synovial fluid (SF) CD4+ Th cells of JIA patients by using flow cytometry and compared cytokine patterns between JIA subgroups. We could show increased frequencies of IL-21 expressing CD4+ Th cells in the joints of ANA+ Oligo-/Poly-JIA patients, which co-expressed the Th-1 cytokines IFN-γ/TNF-α. In contrast, frequencies of IL-17 expressing cells were lowest in the joints of ANA+ Oligo-/Poly-JIA but enriched in that of ERA-JIA patients. This is the first description of a diverse SF Th cell cytokine pattern in different JIA subgroups. Additionally, we could define IL-21 as an effector cytokine expressed in SF Th cell in a significant proportion of ANA+ JIA patients
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Antinuclear antibodies (ANA)
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|a Cytokine pattern interleukin 21 (IL-21)
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|a Juvenile idiopathic arthritis (JIA)
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| 650 |
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4 |
|a interleukin 17 (IL-17)
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| 650 |
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|a Antibodies, Antinuclear
|2 NLM
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| 650 |
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|a IFNG protein, human
|2 NLM
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| 650 |
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|a IL17A protein, human
|2 NLM
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| 650 |
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|a Interleukin-17
|2 NLM
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| 650 |
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|a Interleukins
|2 NLM
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| 650 |
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|a TNF protein, human
|2 NLM
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| 650 |
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|a Tumor Necrosis Factor-alpha
|2 NLM
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| 650 |
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7 |
|a Interferon-gamma
|2 NLM
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| 650 |
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7 |
|a 82115-62-6
|2 NLM
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| 650 |
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|a Interleukin-21
|2 NLM
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| 650 |
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|a MKM3CA6LT1
|2 NLM
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| 700 |
1 |
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|a Dirks, Johannes
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Haase, Gabriele
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Holl-Wieden, Annette
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Hofmann, Christine
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Girschick, Hermann
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Morbach, Henner
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 217(2020) vom: 28. Aug., Seite 108484
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnas
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| 773 |
1 |
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|g volume:217
|g year:2020
|g day:28
|g month:08
|g pages:108484
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| 856 |
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|u http://dx.doi.org/10.1016/j.clim.2020.108484
|3 Volltext
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|a AR
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|d 217
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|h 108484
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