IL-21+ CD4+ T helper cells co-expressing IFN-γ and TNF-α accumulate in the joints of antinuclear antibody positive patients with juvenile idiopathic arthritis

IL-21+ CD4+ T helper cells co-expressing IFN-γ and TNF-α accumulate in the joints of antinuclear antibody positive patients with juvenile idiopathic arthritis

Copyright © 2020 Elsevier Inc. All rights reserved.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 217(2020) vom: 28. Aug., Seite 108484
1. Verfasser: Fischer, Jonas (VerfasserIn)
Weitere Verfasser: Dirks, Johannes, Haase, Gabriele, Holl-Wieden, Annette, Hofmann, Christine, Girschick, Hermann, Morbach, Henner
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2020
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Antinuclear antibodies (ANA) Cytokine pattern interleukin 21 (IL-21) Juvenile idiopathic arthritis (JIA) interleukin 17 (IL-17) Antibodies, Antinuclear IFNG protein, human IL17A protein, human Interleukin-17 mehr... Interleukins TNF protein, human Tumor Necrosis Factor-alpha Interferon-gamma 82115-62-6 Interleukin-21 MKM3CA6LT1
Beschreibung
Zusammenfassung:Copyright © 2020 Elsevier Inc. All rights reserved.
Juvenile Idiopathic Arthritis (JIA) is currently classified into seven subgroups. Recently, antinuclear antibody (ANA) positive JIA patients were suggested to encompass a clinically homogenous new subgroup. CD4+ T helper (Th) cells play an essential role in JIA pathogenesis. Herein, we analyzed cytokine expression in synovial fluid (SF) CD4+ Th cells of JIA patients by using flow cytometry and compared cytokine patterns between JIA subgroups. We could show increased frequencies of IL-21 expressing CD4+ Th cells in the joints of ANA+ Oligo-/Poly-JIA patients, which co-expressed the Th-1 cytokines IFN-γ/TNF-α. In contrast, frequencies of IL-17 expressing cells were lowest in the joints of ANA+ Oligo-/Poly-JIA but enriched in that of ERA-JIA patients. This is the first description of a diverse SF Th cell cytokine pattern in different JIA subgroups. Additionally, we could define IL-21 as an effector cytokine expressed in SF Th cell in a significant proportion of ANA+ JIA patients
Beschreibung:Date Completed 01.02.2021
Date Revised 03.01.2025
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-7035
DOI:10.1016/j.clim.2020.108484