|
|
|
|
| LEADER |
01000caa a22002652c 4500 |
| 001 |
NLM310603978 |
| 003 |
DE-627 |
| 005 |
20250227085543.0 |
| 007 |
cr uuu---uuuuu |
| 008 |
231225s2020 xx |||||o 00| ||eng c |
| 024 |
7 |
|
|a 10.1016/j.clim.2020.108469
|2 doi
|
| 028 |
5 |
2 |
|a pubmed25n1035.xml
|
| 035 |
|
|
|a (DE-627)NLM310603978
|
| 035 |
|
|
|a (NLM)32479990
|
| 035 |
|
|
|a (PII)S1521-6616(20)30119-4
|
| 040 |
|
|
|a DE-627
|b ger
|c DE-627
|e rakwb
|
| 041 |
|
|
|a eng
|
| 100 |
1 |
|
|a Tuerxun, Wuqiekun
|e verfasserin
|4 aut
|
| 245 |
1 |
0 |
|a Expression pattern of the interferon regulatory factor family members in influenza virus induced local and systemic inflammatory responses
|
| 264 |
|
1 |
|c 2020
|
| 336 |
|
|
|a Text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a ƒaComputermedien
|b c
|2 rdamedia
|
| 338 |
|
|
|a ƒa Online-Ressource
|b cr
|2 rdacarrier
|
| 500 |
|
|
|a Date Completed 01.02.2021
|
| 500 |
|
|
|a Date Revised 01.02.2021
|
| 500 |
|
|
|a published: Print-Electronic
|
| 500 |
|
|
|a Citation Status MEDLINE
|
| 520 |
|
|
|a Copyright © 2020. Published by Elsevier Inc.
|
| 520 |
|
|
|a Type I interferon is considered to be a key cytokine in influenza virus-induced acute lung injury (ALI), in which IRF3 and IRF7 play particularly important roles. However, whether all nine members of IRF family are involved in influenza virus-induced immune response is currently unknown. In this study, we found that all members of IRF family responded to influenza virus. The IRF family expression profile seems to be related to the pathogenicity of the particular influenza virus strain. The influenza virus mainly relies on endosomal TLR signals and the positive feedback loop of IFN-I to cause either direct or indirect different expression of all IRF family members locally or systemically. Interestingly, IRF6 was somewhat different from other IRF family members during influenza virus infection. Overall, the expression profile of the IRF family may be a valuable reference for the prevention and treatment of influenza complications, which encourage further, more in-depth research
|
| 650 |
|
4 |
|a Journal Article
|
| 650 |
|
4 |
|a Research Support, Non-U.S. Gov't
|
| 650 |
|
4 |
|a Expression profile
|
| 650 |
|
4 |
|a Influenza virus
|
| 650 |
|
4 |
|a Interferon regulatory factor
|
| 650 |
|
4 |
|a Type I interferon
|
| 650 |
|
7 |
|a Interferon Regulatory Factors
|2 NLM
|
| 650 |
|
7 |
|a Interferon Type I
|2 NLM
|
| 650 |
|
7 |
|a Toll-Like Receptors
|2 NLM
|
| 700 |
1 |
|
|a Wang, Ying
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Cui, Cuiyun
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Yang, Lei
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Wang, Shengnan
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Yu, Yongli
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Wang, Liying
|e verfasserin
|4 aut
|
| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 217(2020) vom: 30. Aug., Seite 108469
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnas
|
| 773 |
1 |
8 |
|g volume:217
|g year:2020
|g day:30
|g month:08
|g pages:108469
|
| 856 |
4 |
0 |
|u http://dx.doi.org/10.1016/j.clim.2020.108469
|3 Volltext
|
| 912 |
|
|
|a GBV_USEFLAG_A
|
| 912 |
|
|
|a SYSFLAG_A
|
| 912 |
|
|
|a GBV_NLM
|
| 912 |
|
|
|a GBV_ILN_11
|
| 912 |
|
|
|a GBV_ILN_24
|
| 912 |
|
|
|a GBV_ILN_350
|
| 951 |
|
|
|a AR
|
| 952 |
|
|
|d 217
|j 2020
|b 30
|c 08
|h 108469
|