|
|
|
|
| LEADER |
01000caa a22002652c 4500 |
| 001 |
NLM31060396X |
| 003 |
DE-627 |
| 005 |
20250227085543.0 |
| 007 |
cr uuu---uuuuu |
| 008 |
231225s2020 xx |||||o 00| ||eng c |
| 024 |
7 |
|
|a 10.1016/j.clim.2020.108483
|2 doi
|
| 028 |
5 |
2 |
|a pubmed25n1035.xml
|
| 035 |
|
|
|a (DE-627)NLM31060396X
|
| 035 |
|
|
|a (NLM)32479989
|
| 035 |
|
|
|a (PII)S1521-6616(20)30080-2
|
| 040 |
|
|
|a DE-627
|b ger
|c DE-627
|e rakwb
|
| 041 |
|
|
|a eng
|
| 100 |
1 |
|
|a Zhao, Lu
|e verfasserin
|4 aut
|
| 245 |
1 |
0 |
|a Immunostaining of galactose-deficient IgA1 by KM55 is not specific for immunoglobulin A nephropathy
|
| 264 |
|
1 |
|c 2020
|
| 336 |
|
|
|a Text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a ƒaComputermedien
|b c
|2 rdamedia
|
| 338 |
|
|
|a ƒa Online-Ressource
|b cr
|2 rdacarrier
|
| 500 |
|
|
|a Date Completed 01.02.2021
|
| 500 |
|
|
|a Date Revised 01.02.2021
|
| 500 |
|
|
|a published: Print-Electronic
|
| 500 |
|
|
|a Citation Status MEDLINE
|
| 520 |
|
|
|a Copyright © 2020 Elsevier Inc. All rights reserved.
|
| 520 |
|
|
|a BACKGROUND: Immunoglobulin A nephropathy (IgAN nephropathy, IgAN) is named for the renal pathological features of IgA-dominant immunoglobulin deposition. IgA deposits, however, may also occur in other diseases, from liver disease and inflammation to chronic infections and tumors. Now increasing studies have suggested that galactose-deficient IgA1 (Gd-IgA1) plays a critical role in the pathogenesis of IgAN. This study aims to investigate whether the Gd-IgA1-specific antibody KM55 contributes to differentiating primary IgAN from other diseases with IgA deposits
|
| 520 |
|
|
|a METHODS: In this retrospective study, we enrolled 100 Chinese patients with IgA deposits in renal biopsies, including IgAN(n = 40), IgAN with hepatitis B virus antigen deposits(n = 14), IgA vasculitis(n = 16), lupus nephritis(n = 11), incidental IgA deposits(n = 13) and negative controls(n = 6). Double immunostaining of Gd-IgA1 and IgA was performed in all biopsies
|
| 520 |
|
|
|a RESULTS: There were similar patterns of Gd-IgA1 deposition in primary IgAN, IgA vasculitis, and IgAN with hepatitis B virus antigen deposits. Gd-IgA1 staining could also be seen in patients with lupus nephritis and incidental IgA deposits, but the intensity was significantly lower than IgAN, and the optimal cutoff was 2+ staining for differential diagnosis. Every increase in KM55 staining intensity of 1+ was associated with an increase in the odds of primary IgAN (OR: 4.399; 95% CI: 1.725-11.216)
|
| 520 |
|
|
|a CONCLUSIONS: Immunostaining for Gd-IgA1 by KM55 is not specific for IgA nephropathy, but weak or negative staining may favor incidental IgA deposits
|
| 650 |
|
4 |
|a Journal Article
|
| 650 |
|
4 |
|a Research Support, Non-U.S. Gov't
|
| 650 |
|
4 |
|a Galactose-deficient IgA1
|
| 650 |
|
4 |
|a Hepatitis B virus
|
| 650 |
|
4 |
|a IgA
|
| 650 |
|
4 |
|a IgA nephropathy
|
| 650 |
|
4 |
|a IgA vasculitis
|
| 650 |
|
4 |
|a Renal biopsy
|
| 650 |
|
7 |
|a Immunoglobulin A
|2 NLM
|
| 650 |
|
7 |
|a Galactose
|2 NLM
|
| 650 |
|
7 |
|a X2RN3Q8DNE
|2 NLM
|
| 700 |
1 |
|
|a Peng, Liang
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Yang, Danyi
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Chen, Shi
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Lan, Zhixin
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Zhu, Xuejing
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Yuan, Shuguang
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Chen, Guochun
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Liu, Yu
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Liu, Hong
|e verfasserin
|4 aut
|
| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 217(2020) vom: 30. Aug., Seite 108483
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnas
|
| 773 |
1 |
8 |
|g volume:217
|g year:2020
|g day:30
|g month:08
|g pages:108483
|
| 856 |
4 |
0 |
|u http://dx.doi.org/10.1016/j.clim.2020.108483
|3 Volltext
|
| 912 |
|
|
|a GBV_USEFLAG_A
|
| 912 |
|
|
|a SYSFLAG_A
|
| 912 |
|
|
|a GBV_NLM
|
| 912 |
|
|
|a GBV_ILN_11
|
| 912 |
|
|
|a GBV_ILN_24
|
| 912 |
|
|
|a GBV_ILN_350
|
| 951 |
|
|
|a AR
|
| 952 |
|
|
|d 217
|j 2020
|b 30
|c 08
|h 108483
|