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231225s2020 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2020.108488
|2 doi
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|a pubmed24n1035.xml
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|a (PII)S1521-6616(20)30413-7
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|a DE-627
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|e rakwb
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|a eng
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| 100 |
1 |
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|a Kolovou, Kyriaki
|e verfasserin
|4 aut
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| 245 |
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|a B-cell oligoclonal expansions in renal tissue of patients with immune-mediated glomerular disease
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|c 2020
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|a Date Completed 01.02.2021
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|a Date Revised 01.02.2021
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2020 Elsevier Inc. All rights reserved.
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|a B-cell clonal expansion has been sporadically described in the blood and/or renal tissue of patients with glomerulonephritides, albeit with unclear pathogenetic role. Herein, using spectratyping analysis, we observed oligoclonal intrarenal B-cell populations in 59% of glomerulonephritis patients with podocyte injury (6/7 with focal segmental glomerulosclerosis, 1/3 minimal change disease, 1/3 idiopathic membranous nephropathy, 3/4 IgA nephropathy, 2/5 membranous lupus nephritis), 20% of glomerulonephritis patients without podocyte involvement (4/13 with mesangial or proliferative lupus nephritis, 0/3 idiopathic membranoproliferative glomerulonephritis, 0/4 pauci-immune vasculitis) and 17% of control patients with renal cancer. In multivariate analysis, oligoclonal B-cells were associated with podocyte injury and the grade of glomerulosclerosis (both p = .009). B-cell oligoclonal expansions were not found in the paired peripheral blood samples. We postulate that B-cell expansion in the kidney results from local stimuli, including antigens expressed on podocytes. Further studies to unravel the role of oligoclonal B-cells in (auto)immune-mediated kidney disease are warranted
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a B-cells
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|a Immune-mediated glomerulonephritis
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| 650 |
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|a Oligoclonal expansion
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| 650 |
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|a Immunoglobulin Heavy Chains
|2 NLM
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| 700 |
1 |
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|a Laskari, Katerina
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Roumelioti, Maria
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Tektonidou, Maria G
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Panayiotidis, Panayiotis
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Boletis, John N
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Marinaki, Smaragdi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Sfikakis, Petros P
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 217(2020) vom: 30. Aug., Seite 108488
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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|g volume:217
|g year:2020
|g day:30
|g month:08
|g pages:108488
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|u http://dx.doi.org/10.1016/j.clim.2020.108488
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