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231225s2020 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2020.108487
|2 doi
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|a pubmed24n1035.xml
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|a (DE-627)NLM310603935
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|a (NLM)32479986
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|a (PII)S1521-6616(20)30452-6
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|a DE-627
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|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Roncati, Luca
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Type 3 hypersensitivity in COVID-19 vasculitis
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|c 2020
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 21.07.2020
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|a Date Revised 06.06.2023
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|a published: Print-Electronic
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|a CommentIn: Hum Cell. 2022 Dec 7;:. - PMID 36478089
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|a Citation Status MEDLINE
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|a Copyright © 2020 Elsevier Inc. All rights reserved.
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|a Coronavirus Disease 2019 (COVID-19) is an ongoing public health emergency and new knowledge about its immunopathogenic mechanisms is deemed necessary in the attempt to reduce the death burden, globally. For the first time in worldwide literature, we provide scientific evidence that in COVID-19 vasculitis a life-threatening escalation from type 2 T-helper immune response (humoral immunity) to type 3 hypersensitivity (immune complex disease) takes place. The subsequent deposition of immune complexes inside the vascular walls is supposed to induce a severe inflammatory state and a cytokine release syndrome, whose interleukin-6 is the key myokine, from the smooth muscle cells of blood vessels
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|a Case Reports
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|a Letter
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| 650 |
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|a Coronavirus disease 2019 (COVID-19)
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| 650 |
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4 |
|a Immune complex disease
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| 650 |
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4 |
|a Interleukin-6 (IL-6)
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| 650 |
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4 |
|a Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
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| 650 |
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4 |
|a Type III hypersensitivity
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| 650 |
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4 |
|a Vasculitis
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| 650 |
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7 |
|a Antibodies, Viral
|2 NLM
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| 650 |
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7 |
|a Antigen-Antibody Complex
|2 NLM
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| 650 |
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7 |
|a Complement C3
|2 NLM
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| 650 |
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|a IL6 protein, human
|2 NLM
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| 650 |
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7 |
|a Immunoglobulin G
|2 NLM
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| 650 |
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7 |
|a Immunoglobulin M
|2 NLM
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| 650 |
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7 |
|a Interleukin-6
|2 NLM
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| 700 |
1 |
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|a Ligabue, Giulia
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Fabbiani, Luca
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Malagoli, Claudia
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Gallo, Graziana
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lusenti, Beatrice
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Nasillo, Vincenzo
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Manenti, Antonio
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Maiorana, Antonio
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 217(2020) vom: 30. Aug., Seite 108487
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
8 |
|g volume:217
|g year:2020
|g day:30
|g month:08
|g pages:108487
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| 856 |
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0 |
|u http://dx.doi.org/10.1016/j.clim.2020.108487
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