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231225s2020 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2020.108482
|2 doi
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|a pubmed24n1035.xml
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|a (DE-627)NLM310510651
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|a (NLM)32470543
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|a (PII)S1521-6616(19)30560-1
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
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|a Bertol, Bruna Cristina
|e verfasserin
|4 aut
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| 245 |
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|a HLA-G liver expression and HLA-G extended haplotypes are associated with chronic hepatitis C in HIV-negative and HIV-coinfected patients
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|c 2020
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 01.02.2021
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|a Date Revised 01.02.2021
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2020 Elsevier Inc. All rights reserved.
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|a Chronic hepatitis C virus (HCV) infection induces liver damage and the HCV/Human Immunodeficiency Virus (HIV)-coinfection may further contribute to its progression. The HLA-G molecule inhibits innate and adaptive immunity and may be deleterious for chronically virus-infected cells. Thus we studied 204 HCV-mono-infected patients, 142 HCV/HIV-coinfected patients, 104 HIV-mono-infected patients and 163 healthy subjects. HLA-G liver expression was similarly induced in HCV and HCV/HIV specimens, increasing with advanced fibrosis and necroinflammatory activity, and with increased levels of liver function-related enzymes. Plasma soluble HLA-G (sHLA-G) levels were higher in HCV/HIV patients compared to HCV, HIV and to healthy individuals. sHLA-G continued to be higher in coinfected patients even after stratification of samples according to degree of liver fibrosis and necroinflammatory activity when compared to mono-infected patients. Some HLA-G gene haplotypes differentiated patient groups and presented few associations with liver and plasma HLA-G expression. HLA-G thus may help to distinguish patient groups
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Antiviral immunity
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| 650 |
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|a HCV/HIV-coinfection
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| 650 |
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|a HLA-G polymorphisms
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| 650 |
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4 |
|a Human leukocyte antigen-G
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| 650 |
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4 |
|a Soluble HLA-G
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| 650 |
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|a HLA-G Antigens
|2 NLM
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| 700 |
1 |
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|a Dias, Fabrício César
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Debortoli, Guilherme
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Souto, Bruno Mendes
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Mendonça, Priscila Baptista
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Araújo, Roberta Chaves
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Santana, Rodrigo Carvalho
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ramalho, Leandra Náira Zambelli
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Castelli, Erick Cruz
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Martinelli, Ana de Lourdes Candolo
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Mendes-Junior, Celso Teixeira
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Carosella, Edgardo Delfino
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Donadi, Eduardo Antônio
|e verfasserin
|4 aut
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| 700 |
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|a Moreau, Philippe
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 217(2020) vom: 30. Aug., Seite 108482
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
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|g volume:217
|g year:2020
|g day:30
|g month:08
|g pages:108482
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| 856 |
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|u http://dx.doi.org/10.1016/j.clim.2020.108482
|3 Volltext
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| 912 |
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|a GBV_USEFLAG_A
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| 912 |
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|a SYSFLAG_A
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| 912 |
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|a GBV_NLM
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| 912 |
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|a GBV_ILN_11
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| 912 |
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|a GBV_ILN_24
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| 912 |
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|a GBV_ILN_350
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| 951 |
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|a AR
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| 952 |
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|d 217
|j 2020
|b 30
|c 08
|h 108482
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