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231225s2020 xx |||||o 00| ||eng c |
| 024 |
7 |
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|a 10.1111/vcp.12859
|2 doi
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|a pubmed25n1033.xml
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|a (DE-627)NLM310147786
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|a (NLM)32432371
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Hurst, Emma A
|e verfasserin
|4 aut
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|a Vitamin D status is seasonally stable in northern European dogs
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|c 2020
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 29.03.2021
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|a Date Revised 29.03.2021
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2020 The Authors. Veterinary Clinical Pathology published by Wiley Periodicals LLC on behalf of American Society for Veterinary Clinical Pathology.
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|a BACKGROUND: Numerous studies in veterinary species have recently linked vitamin D status with nonskeletal health disorders. Previous studies have indicated that dogs cannot produce endogenous vitamin D via cutaneous production and rely solely on dietary intake of vitamin D. The seasonal variation of vitamin D seen in humans due to changes in ultraviolet (UV) exposure, therefore, is unlikely to be replicated in these animals
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|a OBJECTIVES: The objective of this study was to investigate the natural variation in 25-hydroxyvitamin-D concentrations in dogs subject to seasonal UV exposure
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|a METHODS: This longitudinal study followed 18 healthy dogs fed a standardized diet over 1 year, with blood samples obtained monthly. Two key vitamin D metabolites, 25-hydroxyvitamin-D2 and 25-hydroxyvitamin-D3 , were assessed by liquid chromatography-tandem mass spectrometry in serum samples. Various other biochemical parameters were also measured. Seasonality was assessed using cosinor statistical analysis
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|a RESULTS: Although the dogs were subject to seasonally varying UV radiation, 25-hydroxyvitamin-D and related biomarkers (including calcium and parathyroid hormone) remained stable over time and did not follow a seasonal pattern. 25-hydroxyvitamin-D was not positively correlated with exposure to UV radiation. Nonetheless, variation in 25-hydroxyvitamin-D concentrations between individual dogs was detected
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|a CONCLUSIONS: Given the standardization of diet, we concluded that the seasonal stability of 25-hydroxyvitamin-D concentration (vitamin D status) was likely a direct result of lack of cutaneous vitamin D production in this species and highlights the importance of dietary intake. The variation in 25-hydroxyvitamin-D concentration between animals warrants further investigation
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|a Journal Article
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|a 25-hydroxyvitamin-D
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|a LC-MS
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|a season
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|a ultraviolet B
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|a Parathyroid Hormone
|2 NLM
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|a Vitamin D
|2 NLM
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| 650 |
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|a 1406-16-2
|2 NLM
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| 650 |
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|a 25-Hydroxyvitamin D 2
|2 NLM
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| 650 |
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|a 21343-40-8
|2 NLM
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| 650 |
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|a 25-hydroxyvitamin D
|2 NLM
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| 650 |
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|a A288AR3C9H
|2 NLM
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| 650 |
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|a Calcifediol
|2 NLM
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| 650 |
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|a P6YZ13C99Q
|2 NLM
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| 650 |
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|a Calcium
|2 NLM
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| 650 |
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7 |
|a SY7Q814VUP
|2 NLM
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| 700 |
1 |
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|a Homer, Natalie Z
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Gow, Adam G
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Clements, Dylan N
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Evans, Helen
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Gaylor, Donna
|e verfasserin
|4 aut
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| 700 |
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|a Campbell, Susan
|e verfasserin
|4 aut
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| 700 |
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|a Handel, Ian
|e verfasserin
|4 aut
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| 700 |
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|a Mellanby, Richard J
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Veterinary clinical pathology
|d 1975
|g 49(2020), 2 vom: 14. Juni, Seite 279-291
|w (DE-627)NLM098159984
|x 1939-165X
|7 nnas
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| 773 |
1 |
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|g volume:49
|g year:2020
|g number:2
|g day:14
|g month:06
|g pages:279-291
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|u http://dx.doi.org/10.1111/vcp.12859
|3 Volltext
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|a AR
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| 952 |
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|d 49
|j 2020
|e 2
|b 14
|c 06
|h 279-291
|