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231225s2020 xx |||||o 00| ||eng c |
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|a 10.1109/TUFFC.2020.2992764
|2 doi
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|a eng
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1 |
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|a Kuo, Li-Wei
|e verfasserin
|4 aut
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|a An MRI-Guided Ring High-Intensity Focused Ultrasound System for Noninvasive Breast Ablation
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|c 2020
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|a Text
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|a ƒaComputermedien
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|a Date Completed 22.07.2021
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|a Date Revised 22.07.2021
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a High-intensity focused ultrasound (HIFU) has been used for noninvasive treatment of breast tumors, but the present magnetic resonance imaging (MRI)-guided HIFU (MRI-HIFU) systems encounter skin burn. In this study, a novel MRI-HIFU breast ablation system was developed to improve the above problem. The system consisted of the ring HIFU phased-array transducer, a commercial power amplifier, the mechanical positioner, and the graphical user interface control software. MRI thermometry was also established to monitor the temperature in the HIFU-treated tissue. Ablation of pork and the in vivo rabbit leg were carried out to validate the developed system. Results of fat-surrounding pork ablation showed that the ring HIFU system reached a safe margin of 3 mm without fat burn. Moreover, precision of the positioner moving the HIFU focal zone was within 6% error under MRI circumstances. The representative MRI temperature images show that the peak temperatures among the five ablations ranged between 66 °C and 91 °C, and their thermal doses were over 10000. The system could also ablate the biceps femoris of a rabbit without skin burn to form a lesion of 2.5 mm beneath the skin. With the HIFU dose of 315 W/10 s, the MRI temperature map revealed that the maximum temperature and the thermal dose were 60 °C and 3380, respectively. The MRI-guided ring HIFU system can ablate the target tissue near subcutaneous fat without fat burn. The system prototype is a promising tool for clinical implementation
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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1 |
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|a Dong, Guo-Chung
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Pan, Chia-Ching
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chen, Sheng-Fu
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chen, Gin-Shin
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t IEEE transactions on ultrasonics, ferroelectrics, and frequency control
|d 1986
|g 67(2020), 9 vom: 05. Sept., Seite 1839-1847
|w (DE-627)NLM098181017
|x 1525-8955
|7 nnas
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| 773 |
1 |
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|g volume:67
|g year:2020
|g number:9
|g day:05
|g month:09
|g pages:1839-1847
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|u http://dx.doi.org/10.1109/TUFFC.2020.2992764
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