Histopathological examination and transcriptome analyses to assess the acute toxic effects of arsenite exposure on rare minnows (Gobiocypris rarus)

Arsenic is ubiquitously present in the aquatic environment. We investigated the acute toxic effects of arsenite [As(III)] exposure on rare minnows (Gobiocypris rarus) in vivo. The 96-h LC50 value for exposure to As(III) was 13.73 mg/L. As(III) bioaccumulation in different tissues was measured using...

Ausführliche Beschreibung

Bibliographische Detailangaben
Veröffentlicht in:Ecotoxicology (London, England). - 1992. - 29(2020), 5 vom: 08. Juli, Seite 613-624
1. Verfasser: Shi, Lixia (VerfasserIn)
Weitere Verfasser: Hu, Xudong, Wang, Nenghan, Liang, Huifang, Wu, Chenxi, Cao, Hong
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2020
Zugriff auf das übergeordnete Werk:Ecotoxicology (London, England)
Schlagworte:Journal Article Acute arsenic toxicity Histopathology Mitochondria Rare minnow Transcriptome Arsenites Water Pollutants, Chemical
LEADER 01000caa a22002652c 4500
001 NLM309688159
003 DE-627
005 20250227062330.0
007 cr uuu---uuuuu
008 231225s2020 xx |||||o 00| ||eng c
024 7 |a 10.1007/s10646-020-02222-3  |2 doi 
028 5 2 |a pubmed25n1032.xml 
035 |a (DE-627)NLM309688159 
035 |a (NLM)32385600 
040 |a DE-627  |b ger  |c DE-627  |e rakwb 
041 |a eng 
100 1 |a Shi, Lixia  |e verfasserin  |4 aut 
245 1 0 |a Histopathological examination and transcriptome analyses to assess the acute toxic effects of arsenite exposure on rare minnows (Gobiocypris rarus) 
264 1 |c 2020 
336 |a Text  |b txt  |2 rdacontent 
337 |a ƒaComputermedien  |b c  |2 rdamedia 
338 |a ƒa Online-Ressource  |b cr  |2 rdacarrier 
500 |a Date Completed 07.07.2020 
500 |a Date Revised 30.09.2020 
500 |a published: Print-Electronic 
500 |a Citation Status MEDLINE 
520 |a Arsenic is ubiquitously present in the aquatic environment. We investigated the acute toxic effects of arsenite [As(III)] exposure on rare minnows (Gobiocypris rarus) in vivo. The 96-h LC50 value for exposure to As(III) was 13.73 mg/L. As(III) bioaccumulation in different tissues was measured using inductively-coupled plasma mass spectrometry, and the extent of As(III) accumulation was, from greatest to least, liver > intestine > gills > muscle > kidney > testis > brain. Histological examination revealed that in As(III)-treated fish, numerous cellular and tissue alterations were present in the gill, liver, and intestine tissues. Moreover, transmission electron microscopy showed ultrastructural alterations in hepatocytes. We also performed transcriptome analyses to investigate As(III)-induced toxicity response in the liver of As(III)-treated fish; various oxidative-related genes were differentially expressed, and their expression levels were further validated using qPCR. This study is one of the many steps we aim to take on the way to promote the rare minnow to an international standard laboratory animal 
650 4 |a Journal Article 
650 4 |a Acute arsenic toxicity 
650 4 |a Histopathology 
650 4 |a Mitochondria 
650 4 |a Rare minnow 
650 4 |a Transcriptome 
650 7 |a Arsenites  |2 NLM 
650 7 |a Water Pollutants, Chemical  |2 NLM 
700 1 |a Hu, Xudong  |e verfasserin  |4 aut 
700 1 |a Wang, Nenghan  |e verfasserin  |4 aut 
700 1 |a Liang, Huifang  |e verfasserin  |4 aut 
700 1 |a Wu, Chenxi  |e verfasserin  |4 aut 
700 1 |a Cao, Hong  |e verfasserin  |4 aut 
773 0 8 |i Enthalten in  |t Ecotoxicology (London, England)  |d 1992  |g 29(2020), 5 vom: 08. Juli, Seite 613-624  |w (DE-627)NLM098212214  |x 1573-3017  |7 nnas 
773 1 8 |g volume:29  |g year:2020  |g number:5  |g day:08  |g month:07  |g pages:613-624 
856 4 0 |u http://dx.doi.org/10.1007/s10646-020-02222-3  |3 Volltext 
912 |a GBV_USEFLAG_A 
912 |a SYSFLAG_A 
912 |a GBV_NLM 
912 |a GBV_ILN_65 
912 |a GBV_ILN_350 
951 |a AR 
952 |d 29  |j 2020  |e 5  |b 08  |c 07  |h 613-624