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231225s2020 xx |||||o 00| ||eng c |
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|a 10.1093/jxb/eraa213
|2 doi
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|a pubmed25n1031.xml
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|a DE-627
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|a eng
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| 100 |
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|a Bhattacharjee, Samujjal
|e verfasserin
|4 aut
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| 245 |
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|a The tale of caspase homologues and their evolutionary outlook
|b deciphering programmed cell death in cyanobacteria
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|c 2020
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 14.05.2021
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|a Date Revised 01.08.2024
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|a published: Print
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|a Citation Status MEDLINE
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|a © The Author(s) 2020. Published by Oxford University Press on behalf of the Society for Experimental Biology. All rights reserved. For permissions, please email: journals.permissionsoup.com.
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|a Programmed cell death (PCD), a genetically orchestrated mechanism of cellular demise, is paradoxically required to support life. As in lower eukaryotes and bacteria, PCD in cyanobacteria is poorly appreciated, despite recent biochemical and molecular evidence that supports its existence. Cyanobacterial PCD is an altruistic reaction to stressful conditions that significantly enhances genetic diversity and inclusive fitness of the population. Recent bioinformatic analysis has revealed an abundance of death-related proteases, i.e. orthocaspases (OCAs) and their mutated variants, in cyanobacteria, with the larger genomes of morphologically complex strains harbouring most of them. Sequence analysis has depicted crucial accessory domains along with the proteolytic p20-like sub-domain in OCAs, predicting their functional versatility. However, the cascades involved in sensing death signals, their transduction, and the downstream expression and activation of OCAs remain to be elucidated. Here, we provide a comprehensive description of the attempts to identify mechanisms of PCD and the existence and importance of OCAs based on in silico approaches. We also review the evolutionary and ecological significance of PCD in cyanobacteria. In the future, the analysis of cyanobacterial PCD will identify novel proteins that have varied functional roles in signalling cascades and also help in understanding the incipient mechanism of PCD morphotype(s) from where eukaryotic PCD might have originated
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Altruistic adaptation
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|a PCD morphotypes
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|a caspase homologues
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|a horizontal gene transfer
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| 650 |
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|a orthocaspases
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|a programmed cell death
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|a Caspases
|2 NLM
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|a EC 3.4.22.-
|2 NLM
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| 700 |
1 |
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|a Mishra, Arun Kumar
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Journal of experimental botany
|d 1985
|g 71(2020), 16 vom: 06. Aug., Seite 4639-4657
|w (DE-627)NLM098182706
|x 1460-2431
|7 nnas
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| 773 |
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|g volume:71
|g year:2020
|g number:16
|g day:06
|g month:08
|g pages:4639-4657
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|u http://dx.doi.org/10.1093/jxb/eraa213
|3 Volltext
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