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231225s2020 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202001862
|2 doi
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|a pubmed24n1030.xml
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|a eng
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|a Wang, Jinping
|e verfasserin
|4 aut
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|a A Porous Au@Rh Bimetallic Core-Shell Nanostructure as an H2 O2 -Driven Oxygenerator to Alleviate Tumor Hypoxia for Simultaneous Bimodal Imaging and Enhanced Photodynamic Therapy
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|c 2020
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|a Date Completed 02.03.2021
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|a Date Revised 11.11.2023
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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|a In treatment of hypoxic tumors, oxygen-dependent photodynamic therapy (PDT) is considerably limited. Herein, a new bimetallic and biphasic Rh-based core-shell nanosystem (AuRh-ICG-CM) is developed to address tumor hypoxia while achieving high PDT efficacy. Such porous Au@Rh core-shell nanostructures are expected to exhibit catalase-like activity to efficiently catalyze oxygen generation from endogenous hydrogen peroxide in tumors. Coating Au@Rh nanostructures with tumor cell membrane (CM) enables tumor targeting via homologous binding. As a result of the large pores of Rh shells and the trapping ability of CM, the photosensitizer indocyanine green (ICG) is successfully loaded and retained in the cavity of Au@Rh-CM. Au@Rh-ICG-CM shows good biocompatibility, high tumor accumulation, and superior fluorescence and photoacoustic imaging properties. Both in vitro and in vivo results demonstrate that Au@Rh-ICG-CM is able to effectively convert endogenous hydrogen peroxide into oxygen and then elevate the production of tumor-toxic singlet oxygen to significantly enhance PDT. As noted, the mild photothermal effect of Au@Rh-ICG-CM also improves PDT efficacy. By integrating the superiorities of hypoxia regulation function, tumor accumulation capacity, bimodal imaging, and moderate photothermal effect into a single nanosystem, Au@Rh-ICG-CM can readily serve as a promising nanoplatform for enhanced cancer PDT
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|a Journal Article
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|a bimetallic Rh-based core-shell nanostructures
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|a bimodal imaging
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|a endogenous oxygenation
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|a enhanced photodynamic therapy
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|a hypoxia alleviation
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|a Alloys
|2 NLM
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|a Antineoplastic Agents
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|a Biocompatible Materials
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|a Indicators and Reagents
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|a Photosensitizing Agents
|2 NLM
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|a Gold
|2 NLM
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|a 7440-57-5
|2 NLM
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|a Hydrogen Peroxide
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|a BBX060AN9V
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|a Rhodium
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|a DMK383DSAC
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|a Indocyanine Green
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|a IX6J1063HV
|2 NLM
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1 |
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|a Sun, Jingyu
|e verfasserin
|4 aut
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|a Hu, Wei
|e verfasserin
|4 aut
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|a Wang, Yuhao
|e verfasserin
|4 aut
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|a Chou, Tsengming
|e verfasserin
|4 aut
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|a Zhang, Beilu
|e verfasserin
|4 aut
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| 700 |
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|a Zhang, Qiang
|e verfasserin
|4 aut
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| 700 |
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|a Ren, Lei
|e verfasserin
|4 aut
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| 700 |
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|a Wang, Hongjun
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 32(2020), 22 vom: 10. Juni, Seite e2001862
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
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|g volume:32
|g year:2020
|g number:22
|g day:10
|g month:06
|g pages:e2001862
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|u http://dx.doi.org/10.1002/adma.202001862
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