Overexpression of CXCR5 in CD4+ T cells of SLE patients caused by excessive SETD3
Copyright © 2020. Published by Elsevier Inc.
| Veröffentlicht in: | Clinical immunology (Orlando, Fla.). - 1999. - 214(2020) vom: 15. Mai, Seite 108406 |
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| Weitere Verfasser: | , , |
| Format: | Online-Aufsatz |
| Sprache: | English |
| Veröffentlicht: |
2020
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| Zugriff auf das übergeordnete Werk: | Clinical immunology (Orlando, Fla.) |
| Schlagworte: | Journal Article Research Support, Non-U.S. Gov't CXCR5 H3K36me3 H3K4me3 SETD3 SLE CXCR5 protein, human Receptors, CXCR5 Histone Methyltransferases mehr... |
| Zusammenfassung: | Copyright © 2020. Published by Elsevier Inc. The peripheral blood of systemic lupus erythematosus patients showed an increased expression of CXCR5 positive T cells. However, the molecular mechanism of the abnormal expression of CXCR5 in SLE CD4+ T cells remains unclear. The present study demonstrated that the levels of H3K4me3 and H3K36me3 in CXCR5 promoter were significantly higher in SLE patients than those in healthy controls. Furthermore, the expression of SETD3 was upregulated in SLE CD4+ T cells as compared to the healthy controls. Excessive SETD3 increased the level of H3K4me3 and H3K36me3 and promoted the expression of CXCR5. These data strongly suggested that SETD3 plays a major role in the regulation of CXCR5 expression and the progression of SLE |
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| Beschreibung: | Date Completed 16.12.2021 Date Revised 16.12.2021 published: Print-Electronic Citation Status MEDLINE |
| ISSN: | 1521-7035 |
| DOI: | 10.1016/j.clim.2020.108406 |