X-ray fluorescence detection for serial macromolecular crystallography using a JUNGFRAU pixel detector

X-ray fluorescence detection for serial macromolecular crystallography using a JUNGFRAU pixel detector

open access.

Détails bibliographiques
Publié dans:Journal of synchrotron radiation. - 1994. - 27(2020), Pt 2 vom: 01. März, Seite 329-339
Auteur principal: Martiel, Isabelle (Auteur)
Autres auteurs: Mozzanica, Aldo, Opara, Nadia L, Panepucci, Ezequiel, Leonarski, Filip, Redford, Sophie, Mohacsi, Istvan, Guzenko, Vitaliy, Ozerov, Dmitry, Padeste, Celestino, Schmitt, Bernd, Pedrini, Bill, Wang, Meitian
Format: Article en ligne
Langue:English
Publié: 2020
Accès à la collection:Journal of synchrotron radiation
Sujets:Journal Article JUNGFRAU detector XFELs fluorescence macromolecular crystallography serial crystallography silicon drift detectors
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520 |a Detection of heavy elements, such as metals, in macromolecular crystallography (MX) samples by X-ray fluorescence is a function traditionally covered at synchrotron MX beamlines by silicon drift detectors, which cannot be used at X-ray free-electron lasers because of the very short duration of the X-ray pulses. Here it is shown that the hybrid pixel charge-integrating detector JUNGFRAU can fulfill this function when operating in a low-flux regime. The feasibility of precise position determination of micrometre-sized metal marks is also demonstrated, to be used as fiducials for offline prelocation in serial crystallography experiments, based on the specific fluorescence signal measured with JUNGFRAU, both at the synchrotron and at SwissFEL. Finally, the measurement of elemental absorption edges at a synchrotron beamline using JUNGFRAU is also demonstrated 
650 4 |a Journal Article 
650 4 |a JUNGFRAU detector 
650 4 |a XFELs 
650 4 |a fluorescence 
650 4 |a macromolecular crystallography 
650 4 |a serial crystallography 
650 4 |a silicon drift detectors 
700 1 |a Mozzanica, Aldo  |e verfasserin  |4 aut 
700 1 |a Opara, Nadia L  |e verfasserin  |4 aut 
700 1 |a Panepucci, Ezequiel  |e verfasserin  |4 aut 
700 1 |a Leonarski, Filip  |e verfasserin  |4 aut 
700 1 |a Redford, Sophie  |e verfasserin  |4 aut 
700 1 |a Mohacsi, Istvan  |e verfasserin  |4 aut 
700 1 |a Guzenko, Vitaliy  |e verfasserin  |4 aut 
700 1 |a Ozerov, Dmitry  |e verfasserin  |4 aut 
700 1 |a Padeste, Celestino  |e verfasserin  |4 aut 
700 1 |a Schmitt, Bernd  |e verfasserin  |4 aut 
700 1 |a Pedrini, Bill  |e verfasserin  |4 aut 
700 1 |a Wang, Meitian  |e verfasserin  |4 aut 
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773 1 8 |g volume:27  |g year:2020  |g number:Pt 2  |g day:01  |g month:03  |g pages:329-339 
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