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231225s2020 xx |||||o 00| ||eng c |
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|a 10.1155/2020/5052840
|2 doi
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|a pubmed24n1024.xml
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
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|a Ma, Zhen-Zhen
|e verfasserin
|4 aut
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|a Acupuncture Induces Reduction in Limbic-Cortical Feedback of a Neuralgia Rat Model
|b A Dynamic Causal Modeling Study
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|c 2020
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 07.04.2021
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|a Date Revised 07.04.2021
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|a published: Electronic-eCollection
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|a Citation Status MEDLINE
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|a Copyright © 2020 Zhen-Zhen Ma et al.
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|a Background: Neuropathic pain after brachial plexus avulsion remained prevalent and intractable currently. However, the neuroimaging study about neural mechanisms or etiology was limited and blurred
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|a Objective: This study is aimed at investigating the effect of electroacupuncture on effective connectivity and neural response in corticolimbic circuitries during implicit processing of nociceptive stimulus in rats with brachial plexus pain
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|a Methods: An fMRI scan was performed in a total of 16 rats with brachial plexus pain, which was equally distributed into the model group and the electroacupuncture group. The analysis of task-dependent data determined pain-related activation in each group. Based on those results, several regions including AMY, S1, and h were recruited as ROI in dynamic causal modeling (DCM) analysis comparing evidence for different neuronal hypotheses describing the propagation of noxious stimuli in regions of interest and horizontal comparison of effective connections between the model and electroacupuncture groups
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|a Results: In both groups, DCM revealed that noxious stimuli were most likely driven by the somatosensory cortex, with bidirectional propagation with the hypothalamus and amygdala and the interactions in them. Also, the 3-month intervention of acupuncture reduced effective connections of h-S1 and AMY-S1
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|a Conclusions: We showed an evidence that a full connection model within the brain network of brachial plexus pain and electroacupuncture intervention reduces effective connectivity from h and AMY to S1. Our study for the first time explored the relationship of involved brain regions with dynamic causal modeling. It provided novel evidence for the feature of the organization of the cortical-limbic network and the alteration caused by acupuncture
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Lu, Ye-Chen
|e verfasserin
|4 aut
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| 700 |
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|a Wu, Jia-Jia
|e verfasserin
|4 aut
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| 700 |
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|a Xing, Xiang-Xin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Hua, Xu-Yun
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Xu, Jian-Guang
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Neural plasticity
|d 1998
|g 2020(2020) vom: 28., Seite 5052840
|w (DE-627)NLM098558390
|x 1687-5443
|7 nnns
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| 773 |
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|g volume:2020
|g year:2020
|g day:28
|g pages:5052840
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|u http://dx.doi.org/10.1155/2020/5052840
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