Intratracheal aerosolization of viral vectors to newborn pig airways

Gene therapy for airway diseases requires efficient delivery of nucleic acids to the airways. In small animal models, gene delivery reagents are commonly delivered as a bolus dose. However, large animal models are often more relevant for the transition from preclinical studies to human trials. Aeros...

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Détails bibliographiques
Publié dans:BioTechniques. - 1991. - 68(2020), 5 vom: 01. Mai, Seite 235-239
Auteur principal: Cooney, Ashley L (Auteur)
Autres auteurs: Sinn, Patrick L
Format: Article en ligne
Langue:English
Publié: 2020
Accès à la collection:BioTechniques
Sujets:Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't gene therapy gene transfer intubation microsprayer porcine viral vector delivery Aerosols